Rabbit anti-Human OAS2 Polyclonal Antibody | anti-Oas2 antibody
OAS2, CT (2'-5'-oligoadenylate Synthase 2, (2-5')oligo(A) Synthase 2, 2-5A Synthase 2, p69 OAS/p71 OAS, p69OAS/p71OAS)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: ELISA: 1:1,000
Immunohistochemistry: 1:50-1:100
NCBI and Uniprot Product Information
Uniprot Description
OAS2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.7.7.84
Cellular Component: membrane; intracellular membrane-bound organelle; mitochondrion; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: transferase activity; zinc ion binding; RNA binding; metal ion binding; double-stranded RNA binding; nucleotide binding; ATP binding; nucleotidyltransferase activity; 2'-5'-oligoadenylate synthetase activity
Biological Process: immune system process; response to virus; RNA catabolic process; protein myristoylation; protein amino acid glycosylation; innate immune response; immune response; purine nucleotide biosynthetic process; defense response to virus
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Product Notes
The Oas2 oas2 (Catalog #AAA626323) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The OAS2, CT (2'-5'-oligoadenylate Synthase 2, (2-5')oligo(A) Synthase 2, 2-5A Synthase 2, p69 OAS/p71 OAS, p69OAS/p71OAS) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's OAS2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunohistochemistry (IHC). Suitable for use in ELISA and Immunohistochemistry. Dilution: ELISA: 1:1,000 Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the Oas2 oas2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OAS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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