Rabbit NRXN1 Polyclonal Antibody | anti-NRXN1 antibody

NRXN1 Polyclonal Antibody

Cat. Num. AAA9431155

• Gene Names: NRXN1; PTHSL2; SCZD17; Hs.22998
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: NRXN1; Polyclonal Antibody; NRXN1 Polyclonal Antibody; Hs.22998; PTHSL2; SCZD17; neurexin-1; anti-NRXN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 50% glycerol, pH7.4

• Applicable Applications for anti-NRXN1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein of human NRXN1 (NP_001129131.1).
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using NRXN1 antibody.)

Related Product Information for anti-NRXN1 antibody

This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission, and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3, 000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. The RefSeq project has decided to create only a few representative transcript variants of the multitude that are possible. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2.

Product Categories/Family for anti-NRXN1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 208609951
• NCBI GeneID: 9378
• NCBI Accession #: NP_001129131.1
• NCBI GenBank Nucleotide #: NM_001135659.1
• UniProt Accession #: P58400; Q9ULB1
• Molecular Weight: 46,861 Da
• NCBI Official Full Name: neurexin-1-beta isoform alpha2
• NCBI Official Synonym Full Names: neurexin 1
• NCBI Official Symbol: NRXN1
• NCBI Official Synonym Symbols: PTHSL2; SCZD17; Hs.22998
• NCBI Protein Information: neurexin-1-beta; neurexin I
• UniProt Protein Name: Neurexin-1-beta
• Protein Family: Neurexin
• UniProt Gene Name: NRXN1

NCBI Description

Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq, Oct 2008]

Uniprot Description

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis ().