Rabbit Neurofilament M 160kD Polyclonal Antibody | anti-Nefm antibody

Neurofilament M 160kD (NF-M)

Cat. Num. AAA612396

• Gene Names: Nefm; Nfm; NF-M; Nef3; NF160; NF165
• Reactivity: Avian, Feline, Human, Mammal, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Serum; Serum
• Synonyms: Neurofilament M 160kD; Polyclonal Antibody; Neurofilament M 160kD (NF-M); Anti -Neurofilament M 160kD (NF-M); anti-Nefm antibody

• Host: Rabbit
• Reactivity: Avian, Feline, Human, Mammal, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes the evolutionarily conserved extreme C-terminal region of the medium neurofilament subunit (~145-170kDa). Species crossreactivity: Reacts with NF-M from all mammalian, avian and reptiles tested to date, including human, feline, rat, mouse.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as ascites, 0.1% sodium azide.

• Applicable Applications for anti-Nefm antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry, Western Blot.; Dilution: Western Blot 1:5000; Immunohistochemistry 1:1000. Cryostat sections and formalin-fixed paraffin-embedded sections
• Immunogen: Recombinant C-terminal segment of rat NF-M
• Preparation and Storage: -20 degree C

Related Product Information for anti-Nefm antibody

Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-L antibody can also be useful in the neurofilament accumulations seen in many neurological diseases, such as Lou Gehrig's disease or Alzheimerís disease.

Product Categories/Family for anti-Nefm antibody

Antibodies; Abs to Neurofilament

NCBI and Uniprot Product Information

• NCBI GI #: 112363107
• NCBI GeneID: 18040
• NCBI Accession #: NP_032717.2
• NCBI GenBank Nucleotide #: NM_008691.2
• UniProt Accession #: P08553; Q0VDM8; Q3HRJ6; Q3TNS4; Q3TPK2; Q61961; Q8BQ20; A2VCT5
• Molecular Weight: 95,916 Da
• NCBI Official Full Name: neurofilament medium polypeptide
• NCBI Official Synonym Full Names: neurofilament, medium polypeptide
• NCBI Official Symbol: Nefm
• NCBI Official Synonym Symbols: Nfm; NF-M; Nef3; NF160; NF165
• NCBI Protein Information: neurofilament medium polypeptide; neurofilament-M; OTTMUSP00000017611; neurofilament 3, medium; neurofilament protein M; 160 kDa neurofilament protein; neurofilament triplet M protein
• UniProt Protein Name: Neurofilament medium polypeptide
• Protein Family: Neurofilament medium polypeptide
• UniProt Gene Name: Nefm
• UniProt Synonym Gene Names: Nef3; Nfm
• UniProt Entry Name: NFM_MOUSE

Uniprot Description

NFM: a neurofilament intermediate filament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The levels of phosphorylation are altered developmentally and coincident with a change in the neurofilament function.

Protein type: Cytoskeletal

Cellular Component: neuron projection; cytoskeleton; axon; cell; neurofilament; intermediate filament; intracellular; neuromuscular junction; myelin sheath

Molecular Function: structural molecule activity

Biological Process: neurofilament cytoskeleton organization and biogenesis; regulation of axon diameter; axon cargo transport; intermediate filament cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; intermediate filament bundle assembly