Goat anti-Human Neurexin 3 Polyclonal Antibody | anti-NRXN3 antibody

Neurexin 3 (NRXN3, Neurexin 3 Isoform 1 Precursor, KIAA0743, MGC176711, Neurexin III)

Cat. Num. AAA619653

• Gene Names: NRXN3; C14orf60; KIAA0743; MGC176711
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Neurexin 3; Polyclonal Antibody; Neurexin 3 (NRXN3; Neurexin 3 Isoform 1 Precursor; KIAA0743; MGC176711; Neurexin III); Anti -Neurexin 3 (NRXN3; anti-NRXN3 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes the reported isoform 1 (NP_004787.2) of human Neurexin 3. Species sequence homology: mouse, canine, porcine.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-NRXN3 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:4000
• Immunogen: Synthetic peptide with sequence C-PQERKDARSQKNT, from the internal region of human NRXN3 (NP_004787.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-NRXN3 antibody

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.

Product Categories/Family for anti-NRXN3 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 46329869
• NCBI GeneID: 9369
• UniProt Accession #: Q8IUE3; Q9HDB5; Q9Y4C0; Q9Y6S3
• Molecular Weight: 153,885 Da
• NCBI Official Full Name: Neurexin 3
• NCBI Official Synonym Full Names: neurexin 3
• NCBI Official Symbol: NRXN3
• NCBI Official Synonym Symbols: C14orf60; KIAA0743; MGC176711
• NCBI Protein Information: neurexin-3-beta; neurexin III; neurexin III-beta; neurexin III-alpha
• UniProt Protein Name: Neurexin 3-alpha
• Protein Family: Neurexin
• UniProt Gene Name: NRXN3
• UniProt Entry Name: Q8IUE3_HUMAN

NCBI Description

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. [provided by RefSeq]

Uniprot Description

NRXN3: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Belongs to the neurexin family. 7 isoforms of the human protein are produced by alternative promoter.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: integral to plasma membrane; integral to membrane

Molecular Function: metal ion binding; calcium channel regulator activity; cell adhesion molecule binding; receptor activity

Biological Process: positive regulation of synaptogenesis; axon guidance; synaptic transmission; synaptogenesis; neurotransmitter secretion; adult behavior; neuron adhesion; learning; social behavior; angiogenesis