Rabbit anti-Human NRXN3 Polyclonal Antibody | anti-NRXN3 antibody

NRXN3, CT (NRXN3, KIAA0743, Neurexin-3-beta, Neurexin III-beta, Neurexin-3-beta, soluble form, Neurexin-3-beta, C-terminal fragment) (APC)

Cat. Num. AAA6326843

• Gene Names: NRXN3; C14orf60
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: NRXN3; Polyclonal Antibody; CT (NRXN3; KIAA0743; Neurexin-3-beta; Neurexin III-beta; soluble form; C-terminal fragment) (APC); C-terminal fragment; anti-NRXN3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-NRXN3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: NRXN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 435-462 amino acids selected from the C-terminal region of human NRXN3.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(NRXN3 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NRXN3 antibody detected the NRXN3 protein (arrow).)

Related Product Information for anti-NRXN3 antibody

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. [provided by RefSeq].

Product Categories/Family for anti-NRXN3 antibody

Antibodies; KIAA; orf

References

Saus, E., et al. J Psychiatr Res 44(14):971-978(2010). Hotta, K., et al. J. Hum. Genet. (2010). In press: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010). Novak, G., et al. World J. Biol. Psychiatry 10 (4 PT 3), 929-935 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 41350305
• NCBI GeneID: 9369
• NCBI Accession #: NP_620426.2
• NCBI GenBank Nucleotide #: NM_138970.4
• UniProt Accession #: Q9HDB5; Q6NUR0; Q8IUD8; A5PKW8; A8MPU5; B3KPM7; Q9Y4C0
• Molecular Weight: 180,599 Da
• NCBI Official Full Name: neurexin 3 isoform 2
• NCBI Official Synonym Full Names: neurexin 3
• NCBI Official Symbol: NRXN3
• NCBI Official Synonym Symbols: C14orf60
• NCBI Protein Information: neurexin 3
• UniProt Protein Name: Neurexin-3-beta
• Protein Family: Neurexin
• UniProt Gene Name: NRXN3
• UniProt Synonym Gene Names: KIAA0743; NRXN3-CTF
• UniProt Entry Name: NRX3B_HUMAN

NCBI Description

This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]

Uniprot Description

NRXN3B: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis. {ECO:0000250}. Belongs to the neurexin family. {ECO:0000305}. The cytoplasmic C-terminal region binds to CASK. Binds to neuroligins NLGN1, NLGN2 and NLGN3. Weakly interacts with CBLN1 and CBLN2. Very weak binding, if any, with CBLN4. {ECO:0000250}. 7 isoforms of the human protein are produced by alternative promoter

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: integral to plasma membrane; integral to membrane

Molecular Function: metal ion binding; calcium channel regulator activity; receptor activity; cell adhesion molecule binding

Biological Process: synaptic transmission; axon guidance; positive regulation of synaptogenesis; synaptogenesis; neurotransmitter secretion; adult behavior; neuron adhesion; learning; angiogenesis; social behavior