Rabbit anti-Human NALP8 Polyclonal Antibody | anti-NLRP8 antibody

NALP8 Antibody

Cat. Num. AAA150619

• Gene Names: NLRP8; PAN4; NALP8; NOD16; CLR19.2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: NALP8 Antibody is affinity chromatography purified via peptide column.
• Synonyms: NALP8; Polyclonal Antibody; NALP8 Antibody; PAN4; NOD16; CLR19.2; NACHT; LRR and PYD domains-containing protein 8; Nucleotide-binding oligomerization domain protein 16; NLR family; pyrin domain containing 8; anti-NLRP8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: NALP8 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1048

• Applicable Applications for anti-NLRP8 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: NALP8 antibody can be used for detection of NALP8 by Western blot at 1 mug/mL.
• Conjugate: Unconjugated
• Immunogen: NALP8 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human NALP8.
• Buffer: NALP8 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: NALP8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of NALP8 in human colon tissue lysate with NALP8 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Related Product Information for anti-NLRP8 antibody

NALP8 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP8 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It maps to chromosome 19q13.42 and is thought to be expressed in testis and ovary, suggesting that NALP8 may be involved in reproduction. Surprisingly, NALP8 seems to be universal in mammals except for rodents, suggesting that the gene may have been lost during evolution.

NCBI and Uniprot Product Information

• NCBI GI #: 33667040
• NCBI GeneID: 126205
• NCBI Accession #: NP_789781
• NCBI GenBank Nucleotide #: NM_176811.2
• UniProt Accession #: Q86W28; Q7RTR4
• Molecular Weight: 117,336 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 8
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 8
• NCBI Official Symbol: NLRP8
• NCBI Official Synonym Symbols: PAN4; NALP8; NOD16; CLR19.2
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 8; PYRIN and NACHT-containing protein 4; NACHT, LRR and PYD containing protein 8; NACHT, leucine rich repeat and PYD containing 8; nucleotide-binding oligomerization domain protein 16; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 8
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP8
• UniProt Synonym Gene Names: NALP8; NOD16; PAN4
• UniProt Entry Name: NALP8_HUMAN

NCBI Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Uniprot Description

NLRP8: Involved in inflammation (Potential). Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: cytoplasm

Molecular Function: ATP binding