Rabbit Na+ CP type IIbeta Polyclonal Antibody | anti-SCN2B antibody

Na+ CP type IIbeta Polyclonal Antibody

Cat. Num. AAA3006009

• Gene Names: SCN2B; ATFB14
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Na+ CP type IIbeta; Polyclonal Antibody; Na+ CP type IIbeta Polyclonal Antibody; Sodium channel subunit beta-2; SCN2B; ORF Names: UNQ326/PRO386; Na+ CP typeIIbeta; anti-SCN2B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Na+ CP type IIbeta polyclonal antibody detects endogenous levels of Na+ CP type IIbeta protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 215

• Applicable Applications for anti-SCN2B antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 114-159 of Human Na+ CP type IIbeta.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Na+ CP type IIbeta polyclonal antibody at 1:500 dilutionLane1:HEK29T cell lysateLane2:Raw264. 7 cell lysateLane3:Rat liver tissue lysate)

Related Product Information for anti-SCN2B antibody

Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type IIbeta (sodium channel, voltage-gated, typeII, beta), also known as SCN2B, is a 215 amino acid single-pass type I membrane protein that plays a critical role in the expression and assembly of the heterotrimeric complex of the sodium channel and interacts with Tenascin-R to influence the clustering and regulation of sodium channels at nodes of Ranvier. Expressed specifically in brain, Na+ CP type IIbeta contains one Ig-like C2-type (immunoglobulin-like) domain and is encoded by a gene that maps to human chromosome 11q23.3 and mouse chromosome 9 A5.2.

NCBI and Uniprot Product Information

• NCBI GI #: 4759066
• NCBI GeneID: 6327
• NCBI Accession #: NP_004579.1
• NCBI GenBank Nucleotide #: NP_004579.1
• UniProt Accession #: O60939
• Molecular Weight: ~ 24kDa
• NCBI Official Full Name: sodium channel subunit beta-2
• NCBI Official Synonym Full Names: sodium voltage-gated channel beta subunit 2
• NCBI Official Symbol: SCN2B
• NCBI Official Synonym Symbols: ATFB14
• NCBI Protein Information: sodium channel subunit beta-2
• UniProt Protein Name: Sodium channel subunit beta-2
• Protein Family: Sodium channel
• UniProt Gene Name: SCN2B
• UniProt Entry Name: SCN2B_HUMAN

NCBI Description

The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]

Uniprot Description

SCN2B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: voltage-gated sodium channel complex

Molecular Function: sodium channel regulator activity

Biological Process: nervous system development; synaptic transmission; cardiac muscle contraction; response to pyrethroid

Disease: Atrial Fibrillation, Familial, 14