Rabbit MYBBP1A Polyclonal Antibody | anti-MYBBP1A antibody

MYBBP1A Antibody

Cat. Num. AAA9608813

• Gene Names: MYBBP1A; P160; PAP2; Pol5
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: MYBBP1A; Polyclonal Antibody; MYBBP1A Antibody; AL024407; AU019902; cb486; FLJ37886; MBB1A_HUMAN; MYB binding protein (P160) 1a; myb binding protein (P160) 1a like; Myb-binding protein 1A; Mybbp1a; nuclear protein P160; P160; p160MBP; p53 activated protein 2; p67MBP; PAP2; PAR interacting protein; RP23 48A2.3; sb:cb486; anti-MYBBP1A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MYBBP1A antibody detects endogenous levels of total MYBBP1A
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 1332

• Applicable Applications for anti-MYBBP1A antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-3000
• Immunogen: A synthesized peptide derived from human MYBBP1A
• Subcellular Location: Cytoplasm. Nucleus. Nucleus > Nucleolus. Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar.
• Predicted Cross Reactivity: Rabbit
• Similarity: Rabbit (89%)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of MYBBP1A using COLO205 whole cell lysates)

Related Product Information for anti-MYBBP1A antibody

Function: May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter.
Subunit Structure: Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Interacts with CLOCK and CRY1 (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.
Post-translational Modifications: Citrullinated by PADI4.

NCBI and Uniprot Product Information

• NCBI GI #: 157694494
• NCBI GeneID: 10514
• NCBI Accession #: NP_001099008.1
• NCBI GenBank Nucleotide #: NM_001105538.1
• UniProt Accession #: Q9BQG0; Q86VM3; Q9BW49; Q9P0V5; Q9UF99
• Molecular Weight: Observed: 149 kDa; Predicted: 149 kDa
• NCBI Official Full Name: myb-binding protein 1A isoform 1
• NCBI Official Synonym Full Names: MYB binding protein 1a
• NCBI Official Symbol: MYBBP1A
• NCBI Official Synonym Symbols: P160; PAP2; Pol5
• NCBI Protein Information: myb-binding protein 1A
• UniProt Protein Name: Myb-binding protein 1A
• Protein Family: Myb-binding protein
• UniProt Gene Name: MYBBP1A
• UniProt Synonym Gene Names: P160

NCBI Description

This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

May activate or repress transcription via interactions with sequence specific DNA-binding proteins (). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309).