Western Blot (WB)
(Anti- Mucin 5AC Picoband antibody, MBS178193, Western blottingAll lanes: Anti Mucin 5AC (MBS178193) at 0.5ug/mlWB: Recombinant Human Mucin5A Protein 0.5ngPredicted bind size: 68KDObserved bind size: 68KD )
anti-Human Mucin-5AC Polyclonal Antibody | anti-MUC5AC antibody
Anti-Mucin-5AC Antibody
Gene Names
MUC5AC; TBM; leB; MUC5; mucin
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Immunogen Affinity Purified
Synonyms
Mucin-5AC; Polyclonal Antibody; Anti-Mucin-5AC Antibody; Apomucin; Gastric mucin; LeB; Lewis B blood group antigen; Major Airway Glycoprotein; MUC 5; MUC5; MUC5AC; Mucin 5 subtype AC tracheobronchial; Mucin 5 Subtypes A And C; Mucin 5 subtypes A and C tracheobronchial/gastric; Mucin 5AC; Mucin 5AC oligomeric mucus/gel forming; oligomeric mucus/gel forming pseudogene; TBM; Tracheobronchial Mucin; mucin 5AC; oligomeric mucus/gel-forming; anti-MUC5AC antibody
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunogen Affinity Purified
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
5654
Applicable Applications for anti-MUC5AC antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Immunogen
E Coli-derived human Mucin-5AC recombinant protein (Position: D4848-H5030).
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Western Blot (WB)
(Anti- Mucin 5AC Picoband antibody, MBS178193, Western blottingAll lanes: Anti Mucin 5AC (MBS178193) at 0.5ug/mlWB: Recombinant Human Mucin5A Protein 0.5ngPredicted bind size: 68KDObserved bind size: 68KD )
Western Blot (WB)
(Anti- Mucin 5AC Picoband antibody, MBS178193, Western blottingAll lanes: Anti Mucin 5AC (MBS178193) at 0.5ug/mlWB: Recombinant Human Mucin5A Protein 0.5ngPredicted bind size: 68KDObserved bind size: 68KD )
Immunohistochemistry (IHC)
(Anti- Mucin 5AC Picoband antibody, MBS178193, IHC(P)IHC(P): Human Gastric Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- Mucin 5AC Picoband antibody, MBS178193, IHC(P)IHC(P): Human Gastric Cancer Tissue )
Related Product Information for anti-MUC5AC antibody
Description: Rabbit IgG polyclonal antibody for Mucin-5AC(MUC5AC) detection. Tested with WB, IHC-P in Human.
Background: Mucin-5AC is a protein that in humans is encoded by the MUC5AC gene. It is mapped to 11p15.5. MUC5AC is highly expressed in adult trachea and stomach. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease(COPD). It has been showed that activation of the NF-kappa-B signaling pathway by inflammatory cytokine TNF-alpha upregulated MUC5AC mRNA expression nearly 6-fold. MUC5AC is also a direct and critical mediator of resistance during intestinal nematode infection.
Background: Mucin-5AC is a protein that in humans is encoded by the MUC5AC gene. It is mapped to 11p15.5. MUC5AC is highly expressed in adult trachea and stomach. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease(COPD). It has been showed that activation of the NF-kappa-B signaling pathway by inflammatory cytokine TNF-alpha upregulated MUC5AC mRNA expression nearly 6-fold. MUC5AC is also a direct and critical mediator of resistance during intestinal nematode infection.
References
1. Hasnain, S. Z., Evans, C. M., Roy, M., Gallagher, A. L., Kindrachuk, K. N., Barron, L., Dickey, B. F., Wilson, M. S., Wynn, T. A., Grencis, R. K., Thornton, D. J. Muc5ac: a critical component mediating the rejection of enteric nematodes. J. Exp. Med. 208: 893-900, 2011. 2. Moehle, C., Ackermann, N., Langmann, T., Aslanidis, C., Kel, A., Kel-Margoulis, O., Schmitz-Madry, A., Zahn, A., Stremmel, W., Schmitz, G. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J. Molec. Med. 84: 1055-1066, 2006. 3. Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med Genomics5 (1): 21.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
585,570 Da
NCBI Official Full Name
mucin-5AC
NCBI Official Synonym Full Names
mucin 5AC, oligomeric mucus/gel-forming
NCBI Official Symbol
MUC5AC
NCBI Official Synonym Symbols
TBM; leB; MUC5; mucin
NCBI Protein Information
mucin-5AC
UniProt Protein Name
Mucin-5AC
Protein Family
UniProt Gene Name
MUC5AC
UniProt Synonym Gene Names
TBM
UniProt Entry Name
MUC5A_HUMAN
Uniprot Description
MUC5AC iso1:
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; extracellular space; fibril; Golgi lumen
Molecular Function: extracellular matrix structural constituent
Biological Process: fibril organization and biogenesis; O-glycan processing; phosphoinositide-mediated signaling
Research Articles on MUC5AC
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Product Notes
The MUC5AC muc5ac (Catalog #AAA178193) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Mucin-5AC Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Mucin-5AC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the MUC5AC muc5ac for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mucin-5AC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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