Mouse anti-Human Apolipoprotein H Monoclonal Antibody | anti-APOH antibody

Apolipoprotein H Mouse Monoclonal

Cat. Num. AAA766742

• Gene Names: APOH; BG; B2G1; B2GP1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: Apolipoprotein H; Monoclonal Antibody; Apolipoprotein H Mouse Monoclonal; anti-APOH antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 345

• Applicable Applications for anti-APOH antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Apolipoprotein H (beta-2-glycoprotein I)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver using MBS766742 (APOH antibody) at dilution of 1:50)

Western Blot (WB)

(human testis tissue were subjected to SDS PAGE followed by western blot with MBS766742 (APOH antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 178857
• NCBI GeneID: 350
• Molecular Weight: 38,298 Da
• NCBI Official Full Name: apolipoprotein H
• NCBI Official Synonym Full Names: apolipoprotein H
• NCBI Official Symbol: APOH
• NCBI Official Synonym Symbols: BG; B2G1; B2GP1
• NCBI Protein Information: beta-2-glycoprotein 1
• UniProt Protein Name: Beta-2-glycoprotein 1
• Protein Family: Beta-2-glycoprotein
• UniProt Gene Name: APOH
• UniProt Synonym Gene Names: B2G1; Apo-H; B2GPI; Beta(2)GPI
• UniProt Entry Name: APOH_HUMAN

NCBI Description

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

Uniprot Description

APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Protein type: Lipid-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: cell surface; chylomicron; extracellular matrix; extracellular region; extracellular space

Molecular Function: glycoprotein binding; identical protein binding; lipid binding; phospholipid binding; protein binding

Biological Process: blood coagulation, intrinsic pathway; negative regulation of angiogenesis; negative regulation of blood coagulation; negative regulation of endothelial cell proliferation; negative regulation of fibrinolysis; negative regulation of myeloid cell apoptosis; plasminogen activation; platelet degranulation; positive regulation of blood coagulation; positive regulation of lipoprotein lipase activity; regulation of fibrinolysis; triacylglycerol metabolic process; triacylglycerol transport