Immunohistochemistry (IHC)
(Immunochemical staining of human MUC21 in human esophagus with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human MUC21 Polyclonal Antibody | anti-MUC21 antibody
Anti-MUC21 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
MUC21; Polyclonal Antibody; Anti-MUC21 Antibody; Rabbit Polyclonal; MUC21 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-bCX31G15.2 Antibody; Anti-DAAP-223I5.2 Antibody; Anti-KMQK697 Antibody; Anti-MUC-21 Antibody; anti-MUC21 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human MUC21
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-MUC21 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human MUC21 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human MUC21 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human MUC21 in human esophagus with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human MUC21 in human esophagus with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-MUC21 antibody
The mucin family is involved in various aspects of cancer progression, such as cell adhesion, epithelial-mesenchymal transition, cell signaling, and the tumor microenvironment. Mucins either alone or through interactions with receptor tyrosine kinases have been shown to mediate cell signals for the growth and survival of lung cancer cells. Some mucins, MUC1 (CA15-3) and MUC16 (CA125), are useful biomarkers to monitor malignant neoplasms. MUC21 was first identified as a human homologue of mouse Muc21/epiglycanin from human cervical carcinoma cell lines. MUC21 is a transmembrane mucin and is expressed in various human neoplasms including lung carcinomas and is linked with aggressive behavior of neoplastic cells. MUC21 could be a promising biomarker with potential and therapeutic applications for lung adenocarcinoma showing cell incohesiveness.
References
Yoshimoto T, et al. (2019) Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma. Cancer Sci 110 (9): 3006-3011.Tian Y, et al. (2012) Mucin 21 in esophageal squamous epithelia and carcinomas: Analysis with glycoform-specific monoclonal antibodies. Glycobiology 22 (9): 1218-1226.Matsumura M, et al. (2019) Specific expression of muc21 in micropapillary elements of lung adenocarcinomas-implications for the progression of egfr-mutated lung adenocarcinomas. PLoS One 14 (4): e0215237.
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Product Notes
The MUC21 (Catalog #AAA8110463) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MUC21 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MUC21 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the MUC21 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MUC21, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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