Immunohistochemistry (IHC)
(Immunochemical staining of human ERCC6L in human colon with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human ERCC6L Polyclonal Antibody | anti-ERCC6L antibody
Anti-ERCC6L Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
ERCC6L; Polyclonal Antibody; Anti-ERCC6L Antibody; Rabbit Polyclonal; ERCC6L Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-PICH Antibody; Anti-RAD26L Antibody; anti-ERCC6L antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human ERCC6L
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-ERCC6L antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human ERCC6L fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human ERCC6L fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human ERCC6L in human colon with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human ERCC6L in human colon with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-ERCC6L antibody
A newly identified ERCC6-like gene in mice, ERCC6L, also known as polo-like kinase 1 (PLK1)-interacting checkpoint helicase, has been demonstrated to be a development-associated member of the SNF2 family. Excision repair cross-complementation group 6 like (ERCC6L) is highly expressed in a variety of human cancer types. The ERCC6L protein is assembled in the cytoplasm and then enters the cell nucleus to exert its function. It is strongly expressed in the mouse embryonic stage, particularly in embryonic brain, heart, kidney, liver and lung. ERCC6L silencing has been revealed to inhibit the proliferation of cancer cells, which suggests that ERCC6L may be an effective biomarker for cancer progression.
References
Huang Y, et al. (2019) Loss of pich promotes chromosome instability and cell death in triple-negative breast cancer. Cell Death Dis 10 (6): 428.Zhang G, et al. (2019) Ercc6l that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating mapk signalling pathway. Cancer Gene Ther 26 (9-10): 323-333.
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Product Notes
The ERCC6L (Catalog #AAA8108804) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ERCC6L Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ERCC6L can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the ERCC6L for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERCC6L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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