Immunohistochemistry (IHC)
(Immunochemical staining of human TNC in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human TNC Polyclonal Antibody | anti-TNC antibody
Anti-TNC Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
TNC; Polyclonal Antibody; Anti-TNC Antibody; Rabbit Polyclonal; TNC Antibody; Rabbit PAb; Antigen Affinity Purified; tenascin C; Anti-150-225 Antibody; Anti-DFNA56 Antibody; Anti-GMEM Antibody; Anti-GP Antibody; Anti-HXB Antibody; Anti-JI Antibody; Anti-MGC167029 Antibody; Anti-TN Antibody; Anti-TN-C Antibody; anti-TNC antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human TNC
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-TNC antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human TNC fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human TNC fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human TNC in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human TNC in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-TNC antibody
Tenascin C (TNC) is an extracellular matrix glycoprotein, expressed in the CNS during development, as well as in the setting of inflammation, fibrosis, and cancer, which operates as an activator of Toll-like receptor 4 (TLR4). TNC consists of four distinct domains, including the tenascin assembly domain, epidermal growth factor-like repeats, fibronectin type III-like repeats, and the fibrinogen-like globe (FBG) domain. TNC plays an important role in cancer cell proliferation and migration and tumor invasion in various types of cancer. A high level of TNC as a potential biomarker of cancer-associated fibroblasts (CAFs) was significantly correlated with the poor prognosis for prostate cancer patients. TNC is overexpressed in human glioblastomas, leading to a highly motile and invasive phenotype of glioma cells.
References
Zhang JF, et al. (2019) Il-33/st2 axis promotes glioblastoma cell invasion by accumulating tenascin-c. Sci Rep 9 (1): 20276.Ni WD, et al. (2017) Tenascin-c is a potential cancer-associated fibroblasts marker and predicts poor prognosis in prostate cancer. Biochem Biophys Res Commun 486 (3): 607-612.Hasegawa M, et al. (2018) Role of tenascin-c in articular cartilage. Mod Rheumatol 28 (2): 215-220.Haage V, et al. (2019) Tenascin c regulates multiple microglial functions involving tlr4 signaling and hdac1. Brain Behav Immun 81 470-483.
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Product Notes
The TNC (Catalog #AAA8109310) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TNC Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TNC can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the TNC for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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