Rabbit MRS (Methionyl-tRNA Synthetase) Polyclonal Antibody | anti-MRS antibody

MRS (Methionyl-tRNA Synthetase)

Cat. Num. AAA490297

• Reactivity: Human, Mouse; Other species are not tested.
• Applications: Immunofluorescence, Western Blot
• Synonyms: MRS (Methionyl-tRNA Synthetase); Polyclonal Antibody; Methionyl-tRNA Synthetase pAb; MARS; MetRS; anti-MRS antibody

• Host: Rabbit
• Reactivity: Human, Mouse; Other species are not tested.
• Clonality: Polyclonal
• Specificity: This antibody reacts specifically with 100kDa methionyl tRNA synthetase protein.
• Form/Format: Serum containing 0.05% sodium azide for preservative.
• Sequence Length: 530

• Applicable Applications for anti-MRS antibody: Immunofluorescence (IF), Western Blot (WB)
• Application Notes: WB: 1:8000
• Immunogen: Denatured full length human recombinant MRS.
• Preparation and Storage: Store at 4 degree C or -20 degree C.

Western Blot (WB)

Western Blot (WB)

Immunofluorescence (IF)

Related Product Information for anti-MRS antibody

MRS is a component of multi-ARS complex and catalyzes ligation of methionine with methionyl-tRNA. MRS is involved in the rRNA synthesis in nucleoli.

References

1. Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyltRNA synthetase-interacting multifunctional protein-3. Nam Hoon Kwon et al., PNAS. Vol.108(49), 19635-19640, 2011. 2. 2-[2-Substituted-3-(3,4-dichlorobenzylamino) propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. Farhanullah et al., European Journal of Medicinal Chemistry, Vol.44, 239-250, 2009. 3. Design and synthesis of quinolinones as methionyltRNA synthetase inhibitors. Jeewoo Lee et al., Bioorganic & Medicinal Chemistry, Vol.14, 7154-7159, 2006. 4. Pharmacophore-based virtual screening: The discovery of novel methionyl-tRNA synthetase inhibitors. Su Yeon Kim et al., Bioorganic & Medicinal Chemistry Letters, Vol.16, 4898-4907, 2006. 5. Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. Sung Eun Kim et al., Bioorganic & Medicinal Chemistry Letters, Vol.15, 3389-3393, 2005. 6. Vanilloid and Isovanilloid Analogues as Inhibitors of Methionyl-tRNA and Isoleucyl-tRNA Synthetases. Jeewoo Lee et al., Bioorganic & Medicinal Chemistry Letters, Vol.11, 965-968, 2001. 7. Ester and Hydroxamate Analogues of Methionyl and Isoleucyl Adenylates as Inhibitors of Methionyl-tRNA and Isoleucyl-tRNA Synthetases. Jeewoo Lee et al., Bioorganic & Medicinal Chemistry Letters, Vol.11, 961-964, 2001. 8. Nucleolar Localization of Human Methionyl-tRNA Synthetase and Its Role in Ribosomal RNA Synthesis. Younggyu Ko et al., J. Cell Biol, Vol.149, 567-574, 2000. 9. Methionine Analogue Probes Functionally Important Residues in Active Site of Methionyl-tRNA Synthetase. Young Joon Jo et al., Journal of biochem and mol biol, Vol.32(6), 547-553, 1999. 10. Methionyl Adenylate Analogues as Inhibitors of Methionyl-tRNA Synthetase. Jeewoo Lee et al., Bioorganic & Medicinal Chemistry Letters, Vol.9, 1365-1370, 1999. 11. Methionine Analogues as Inhibitors of MethionyltRNA Synthetase. Jeewoo Lee et al., Bioorganic & Medicinal Chemistry Letters, Vol.8, 3511-3514, 1998. 12. Cloning and characterization of mitochondrial methionyl-tRNA synthetase from a pathogenic fungi Candida albicans. Sang Won Lee et al., Gene, Vol.215, 311-318, 1998. 13. Biochemical and phylogenetic analyses of methionyl-tRNA synthetase isolated from a pathogenic microorganism, Mycobacterium tuberculosis. Sunghoon Kim et al., FEBS Letters, Vol.427, 259-262, 1998.

NCBI and Uniprot Product Information

• NCBI GI #: 1003019281
• NCBI Official Full Name: methionyl tRNA synthetase