Western Blot (WB)
Rabbit KRS (Lysyl-tRNA Synthetase) Polyclonal Antibody | anti-KRS antibody
KRS (Lysyl-tRNA Synthetase)
Gene Names
KARS; KRS; KARS1; KARS2; CMTRIB; DFNB89
Reactivity
Human, MouseOther species are not tested.
Applications
Western Blot, Immunohistochemistry
Synonyms
KRS (Lysyl-tRNA Synthetase); Polyclonal Antibody; Iysyl-tRNA Synthetase pAb; KARS; LysylRS; anti-KRS antibody
Host
Rabbit
Reactivity
Human, Mouse
Other species are not tested.
Other species are not tested.
Clonality
Polyclonal
Specificity
This antibody specifically reacts with 74kDa lysyl-tRNA synthetase protein.
Form/Format
Serum containing 0.05% sodium azide for preservative.
Sequence Length
597
Applicable Applications for anti-KRS antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:8000
Immunogen
Full length native human recombinant KRS.
Preparation and Storage
Store at 4 degree C or -20 degree C.
Western Blot (WB)
Western Blot (WB)
Western Blot (WB)
Western Blot (WB)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Related Product Information for anti-KRS antibody
lysyl-tRNA synthetase (KRS) is a component of multi-ARS complex and catalyzes the ligation of lysine with lysyl-tRNA. KRS is secreted from cancer cell by TNFa and activates monocyte/macrophage. KRS is also a component of capsid proteins of HIV.
References
1. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Dae Gyu Kim et al., NATURE CHEMICAL BIOLOGY, 10 November, 2013. 2. Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription. Yifat Ofir-Birin et al., Molecular Cell, Vol.49, 1-13, 2013. 3. Entamoeba lysyl-tRNA Synthetase Contains a Cytokine-Like Domain with Chemokine Activity towards Human Endothelial Cells. Manuel Castro de Moura et al. 4. Human lysyl-tRNA synthetase is secreted to trigger pro-inflammatory response. Sanggyu Park et al., Proc. Natl. Acad. Sci., Vol.102, 6356-6361, 2005. 5. Cellular Distribution of lysyl-tRNA Synthetase and Its Interaction with Gag during Human Immunodeficiency Virus Type 1 Assembly. Rabih Halwani et al., JOURNAL OF VIROLOGY, Vol.78, 7553-7564, 2004.
NCBI and Uniprot Product Information
NCBI Description
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Research Articles on KRS
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Product Notes
The KRS (Catalog #AAA490299) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KRS (Lysyl-tRNA Synthetase) reacts with Human, Mouse Other species are not tested. and may cross-react with other species as described in the data sheet. AAA Biotech's KRS (Lysyl-tRNA Synthetase) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:8000. Researchers should empirically determine the suitability of the KRS for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KRS (Lysyl-tRNA Synthetase), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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