Western Blot (WB)
Rabbit AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2) Polyclonal Antibody | anti-AIMP2 antibody
AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2)
Reactivity
Human, MouseOther species are not tested.
Applications
Western Blot, Immunofluorescence
Synonyms
AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2); Polyclonal Antibody; Aminoacyl tRNA Synthetase complexinteracting multifunctional protein 2 pAb; JTV-1; p38; PRO0992; anti-AIMP2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Other species are not tested.
Other species are not tested.
Clonality
Polyclonal
Specificity
This antibody reacts specifically with 38kDa AIMP2(JTV-1) protein.
Form/Format
Serum containing 0.05% sodium azide for preservative.
Sequence Length
241
Applicable Applications for anti-AIMP2 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes
WB: 1:3000-1:8000
Immunogen
Denatured full length native recombinant human AIMP2.
Preparation and Storage
Store at 4 degree C or -20 degree C.
Western Blot (WB)
Western Blot (WB)
Western Blot (WB)
Western Blot (WB)
Immunofluorescence (IF)
Immunofluorescence (IF)
Related Product Information for anti-AIMP2 antibody
AIMP2 is an important component for association of ARS multi-complex. AIMP2 is a potent tumor suppressor. AIMP2 inhibit c-myc activity in TGFbeta signaling, link c-IAP1 to TRAF2 by TNF-alpha stimulation and activate p53 under DNA-damaged condition.
References
1. Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression. Hee Sook LEE et al., Biochem. J. Vol.454, 411-416, 2013. 2. Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer. Jin Woo Choi et al., Journal of Molecular Cell Biology, Vol.4, 164-173, 2012. 3. Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis. Jin Woo Choi et al., PLoS Genetics, Vol.7, Issue 3, e1001351, 2011. 4. AIMP2/p38 promotes TNF-alpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2. Jinwoo Choi et al, J. Cell Sci, Vol.122, 2710-2715, 2009.5. Multi-directional tumor suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to multi-organ carcinogenesis. Jinwoo Choi et al., Carcinogenesis, Vol.30, 1638-1644, 2009. 6. AIMP2/p38, the scaffold for multi-tRNA synthetase complex, responds to genotoxic stresses via p53. Jung Min Han et al., PNAS, Vol.105, 11206-11211, 2008. 7. Accumulation of the Authentic Parkin Substrate AminoacyltRNA Synthetase Cofactor, p38/JTV-1, Leads to Catecholaminergic Cell Death. Han Seok Ko et al., The Journal of Neuroscience, Vol.25(35), 7968-7978, 2005. 8. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Min Jung Kim et al., NATURE GENETICS, Vol.34(3), 2003. 9. Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43. Hee-Chul Ahn et al., FEBS Letters, Vol.542, 119-124, 2003. 10. p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: Implications for its physiological significance. Jin Young Kim et al., PNAS, Vol.99(12), 7912-7916, 2002.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
NCBI Official Symbol
AIMP2
NCBI Protein Information
aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Similar Products
Product Notes
The AIMP2 (Catalog #AAA490305) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2) reacts with Human, Mouse Other species are not tested. and may cross-react with other species as described in the data sheet. AAA Biotech's AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). WB: 1:3000-1:8000. Researchers should empirically determine the suitability of the AIMP2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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