Rabbit MRP-S36 Polyclonal Antibody | anti-MRP-S36 antibody

MRP-S36 (V36) Polyclonal Antibody

Cat. Num. AAA3004418

• Gene Names: MRPS36; DC47; MRP-S36
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: MRP-S36; Polyclonal Antibody; MRP-S36 (V36) Polyclonal Antibody; 28S ribosomal protein S36; mitochondrial; S36mt; MRPS36; ORF Names: DC47; anti-MRP-S36 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MRP-S36 (V36) polyclonal antibody detects endogenous levels of MRP-S36 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 103

• Applicable Applications for anti-MRP-S36 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to the N-terminal of Human MRP-S36.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of MRP-S36 (V36) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.)

Related Product Information for anti-MRP-S36 antibody

Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-S36 (mitochondrial ribosomal protein S36), is a 103 amino acid protein that localizes to the mitochondrion, where it exists as a component of the 28S ribosomal subunit and works in conjunction with other MRPs to mediate protein synthesis. The gene encoding MRP-S36 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

NCBI and Uniprot Product Information

• NCBI GI #: 15150811
• NCBI GeneID: 92259
• NCBI Accession #: NP_150597.1
• NCBI GenBank Nucleotide #: NP_150597.1
• UniProt Accession #: P82909
• Molecular Weight: ~ 15kDa
• NCBI Official Full Name: 28S ribosomal protein S36, mitochondrial
• NCBI Official Synonym Full Names: mitochondrial ribosomal protein S36
• NCBI Official Symbol: MRPS36
• NCBI Official Synonym Symbols: DC47; MRP-S36
• NCBI Protein Information: 28S ribosomal protein S36, mitochondrial
• UniProt Protein Name: 28S ribosomal protein S36, mitochondrial
• UniProt Gene Name: MRPS36
• UniProt Synonym Gene Names: MRP-S36; S36mt
• UniProt Entry Name: RT36_HUMAN

NCBI Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]

Uniprot Description

MRPS36: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein type: Ribosomal; Translation; Mitochondrial

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial small ribosomal subunit

Molecular Function: structural constituent of ribosome

Biological Process: mitochondrial translation; translation; organelle organization and biogenesis