Typical Testing Data/Standard Curve (for reference only)
Mouse Disabled homolog 2 ELISA Kit | Dab2 elisa kit
Mouse Disabled homolog 2 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.
NCBI and Uniprot Product Information
Uniprot Description
DAB2: an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described.
Protein type: Adaptor/scaffold; Tumor suppressor
Cellular Component: apical plasma membrane; clathrin coat of coated pit; clathrin coated vesicle membrane; clathrin-coated vesicle; coated pit; cytoplasm; cytoplasmic vesicle; focal adhesion; intracellular membrane-bound organelle; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: clathrin binding; integrin binding; phosphatidylinositol-4,5-bisphosphate binding; phosphoinositide binding; protein binding; protein C-terminus binding; SMAD binding
Biological Process: activation of JNK activity; apoptosis; cell differentiation; cellular morphogenesis during differentiation; clathrin cage assembly; endocytosis; endoderm development; excretion; in utero embryonic development; leading edge cell differentiation; multicellular organismal development; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; pinocytosis; positive regulation of aldosterone biosynthetic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of endocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of receptor internalization; positive regulation of receptor recycling; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; protein transport; receptor-mediated endocytosis; response to steroid hormone stimulus; transport; Wnt receptor signaling pathway
Research Articles on Dab2
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Product Notes
The Mouse Dab2 dab2 (Catalog #AAA2882959) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2882959 ELISA Kit recognizes Mouse Dab2. It is sometimes possible for the material contained within the vial of "Disabled homolog 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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