Rabbit anti-Human MRGPRX1 Polyclonal Antibody | anti-MRGPRX1 antibody

MRGPRX1 Polyclonal Antibody

Cat. Num. AAA2523948

• Gene Names: MRGPRX1; GPCR; MGRG2; MRGX1; SNSR4
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: MRGPRX1; Polyclonal Antibody; MRGPRX1 Polyclonal Antibody; C1 R; C1R; Complement component 1 subcomponent r; anti-MRGPRX1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
• Sequence Length: 322

• Applicable Applications for anti-MRGPRX1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide of human MRGPRX1
• Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using MRGPRX1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using MRGPRX1 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-MRGPRX1 antibody

MRGX1 is an opiod receptor that has been reported exclusively in dorsal root ganglion. MRGX1 is probably involved in the function of nociceptive neurons and may regulate nociceptor function and/or development, including the sensation or modulation of pain. It is potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells.

NCBI and Uniprot Product Information

• NCBI GI #: 125660451
• NCBI GeneID: 259249
• NCBI Accession #: NP_671732
• NCBI GenBank Nucleotide #: NM_147199.3
• UniProt Accession #: Q96LB2; Q4V9L2; Q8TDD8; Q8TDD9
• NCBI Official Full Name: mas-related G-protein coupled receptor member X1
• NCBI Official Synonym Full Names: MAS-related GPR, member X1
• NCBI Official Symbol: MRGPRX1
• NCBI Official Synonym Symbols: GPCR; MGRG2; MRGX1; SNSR4
• NCBI Protein Information: mas-related G-protein coupled receptor member X1; G protein-coupled receptor MRGX1; G protein-coupled receptor SNSR3; Mas-related G protein-coupled receptor G2; sensory neuron-specific G-protein coupled receptor 3/4
• UniProt Protein Name: Mas-related G-protein coupled receptor member X1
• Protein Family: Mas-related G-protein coupled receptor
• UniProt Gene Name: MRGPRX1
• UniProt Synonym Gene Names: MRGX1; SNSR3; SNSR4
• UniProt Entry Name: MRGX1_HUMAN

Uniprot Description

MRGPRX1: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in an histamine-independent manner. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11p15.1|11

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; acute-phase response