Rabbit anti-Human MRGPRX1 Polyclonal Antibody | anti-MRGPRX1 antibody

MRGPRX1 Antibody

Cat. Num. AAA9404735

• Gene Names: MRGPRX1; GPCR; MGRG2; MRGX1; SNSR4
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: MRGPRX1; Polyclonal Antibody; MRGPRX1 Antibody; GPCR; MGRG2; MRGX1; SNSR4; anti-MRGPRX1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total MRGPRX1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.7 mg/ml (varies by lot)
• Sequence Length: 322

• Applicable Applications for anti-MRGPRX1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human MAS-related GPR, member X1
• Target Name: MRGPRX1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/20.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/20.)

Related Product Information for anti-MRGPRX1 antibody

MRGX1 is an opiod receptor that has been reported exclusively in dorsal root ganglion. MRGX1 is probably involved in the function of nociceptive neurons and may regulate nociceptor function and/or development, including the sensation or modulation of pain. It is potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells.

Product Categories/Family for anti-MRGPRX1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 125660451
• NCBI GeneID: 259249
• NCBI Accession #: NP_671732.3
• NCBI GenBank Nucleotide #: NM_147199.3
• UniProt Accession #: Q96LB2; Q4V9L2; Q8TDD8; Q8TDD9
• Molecular Weight: 36,250 Da
• NCBI Official Full Name: mas-related G-protein coupled receptor member X1
• NCBI Official Synonym Full Names: MAS-related GPR, member X1
• NCBI Official Symbol: MRGPRX1
• NCBI Official Synonym Symbols: GPCR; MGRG2; MRGX1; SNSR4
• NCBI Protein Information: mas-related G-protein coupled receptor member X1
• UniProt Protein Name: Mas-related G-protein coupled receptor member X1
• Protein Family: Mas-related G-protein coupled receptor
• UniProt Gene Name: MRGPRX1
• UniProt Synonym Gene Names: MRGX1; SNSR3; SNSR4
• UniProt Entry Name: MRGX1_HUMAN

Uniprot Description

MRGPRX1: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in an histamine-independent manner. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 11p15.1|11

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; acute-phase response