Rabbit anti-Rat Melanocortin Receptor 2 Polyclonal Antibody | anti-MC2R antibody

Anti-Melanocortin Receptor 2 (Extracellular) Antibody

Cat. Num. AAA4157636

• Gene Names: MC2R; ACTHR
• Reactivity: Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: Melanocortin Receptor 2; Polyclonal Antibody; Anti-Melanocortin Receptor 2 (Extracellular) Antibody; anti-MC2R antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 297

• Applicable Applications for anti-MC2R antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Peptide (C)RNMGYLKPRGSFE corresponding to amino acid residues 87-99 of human MC2R (Accession Q01718).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Testing Data

Related Product Information for anti-MC2R antibody

Melanocortin Receptor 2 (MC2R) belongs to a five-member receptor family known as the melanocortin receptors. The melanocortin receptors are members of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. The receptors ligands, the melanocortins, are a group of structurally derived peptides consisting of a-, b-and g-melanocyte stimulating hormone (a, b, g-MSH) and the adrenocorticotropic hormone (ACTH) all of which are derived from the post-translational processing of a common precursor peptide, proopiomelanocortin (POMC).1, 2, 3 One of the most salient features of the melanocortin signaling system is the presence of two endogenous antagonists, that is proteins that bind specifically to the receptor but instead of activating it have an inhibitory effect. The antagonist proteins are termed agouti (or agouti signaling protein, ASP) and agouti-related protein (AGRP).4 All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti and AGRP) with different affinities. MC2R can be also described as the ACTH receptor as it is exclusively activated by the ACTH hormone. In fact, MC2R mediates all the physiological effects of ACTH in the adrenal cortex, that is the regulation and production of steroids, their circadian variation and their stress-related fluctuations.1, 2, 3 In addition, mutations that result in MC2R functional impairment are associated with familial glucocorticoid deficiency.4 The receptor transduces signals via Gs resulting in the activation of adenylate cyclase and production of cAMP. This antibody can be used in Western blot and immunohistochemistry applications and will recognize human, mouse and rat samples.

NCBI and Uniprot Product Information

• NCBI GI #: 29293646
• NCBI GeneID: 4158
• NCBI Official Full Name: melanocortin 2 receptor
• NCBI Official Synonym Full Names: melanocortin 2 receptor
• NCBI Official Symbol: MC2R
• NCBI Official Synonym Symbols: ACTHR
• NCBI Protein Information: adrenocorticotropic hormone receptor
• Protein Family: Adrenocorticotropic hormone receptor

NCBI Description

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]