Western Blot (WB)
(Western Blot analysis of WiDr cell line lysates (15ug/lane) using MBS6000599. This demonstrates that MBS6000599 detected the MC2R protein (arrow).)
Rabbit anti-Human MC2R Polyclonal Antibody | anti-MC2R antibody
MC2R, CT (MC2R, ACTHR, Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50
Western Blot (WB)
(Western Blot analysis of WiDr cell line lysates (15ug/lane) using MBS6000599. This demonstrates that MBS6000599 detected the MC2R protein (arrow).)
Western Blot (WB)
(Western Blot analysis of WiDr cell line lysates (15ug/lane) using MBS6000599. This demonstrates that MBS6000599 detected the MC2R protein (arrow).)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma using MBS6000599 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6000599 for immunohistochemistry.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma using MBS6000599 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6000599 for immunohistochemistry.)
Flow Cytometry (FC/FACS)
(Flow Cytometric analysis of WiDr cells (right histogram) using MBS6000599 compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(Flow Cytometric analysis of WiDr cells (right histogram) using MBS6000599 compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
NCBI and Uniprot Product Information
NCBI Description
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq, Jul 2008]
Uniprot Description
MC2R: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1); also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18p11.2
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: protein binding; melanocortin receptor activity; adrenocorticotropin receptor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; placenta development
Disease: Glucocorticoid Deficiency 1
Research Articles on MC2R
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Product Notes
The MC2R mc2r (Catalog #AAA6000599) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MC2R, CT (MC2R, ACTHR, Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, Melanocortin receptor 2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MC2R can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100 Flow Cytometry: 1:10-50. Researchers should empirically determine the suitability of the MC2R mc2r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MC2R, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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