Rabbit MEK1 Polyclonal Antibody | anti-MEK1 antibody

MEK1 antibody

Cat. Num. AAA5309793

• Gene Names: MEK1; ATMEK1; F20B18.180; F20B18_180; MAP kinase/ ERK kinase 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MKK1; NMAPKK
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by immunoaffinity chromatography.
• Synonyms: MEK1; Polyclonal Antibody; MEK1 antibody; Rabbit polyclonal MEK1 antibody; Polyclonal MEK1 antibody; Anti-MEK1 antibody; MEK-1 antibody; MEK-1; MAP2K1 antibody; MKK1 antibody; MEK 1 antibody; Ab 291 antibody; PRKMK1 antibody; MEK 1; MAPKK1 antibody; anti-MEK1 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Purity/Purification: Purified by immunoaffinity chromatography.
• Form/Format: Liquid form in PBS buffer (no MG2+ or Ca2+), pH 7.4, 150 mm NaCl,0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 354

• Applicable Applications for anti-MEK1 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:100; WB: 1:500-1:1000
• Immunogen: MEK1 antibody was raised in Rabbit using the peptide sequence around aa 289~293 (P-R-T-P-G) derived from Human MEK1 as the immunogen.
• Cross-Reactivity: Human, Mouse, Rat
• Preparation and Storage: Store at 4 degree C for short term storage.; Aliquot and store at-20 degree C for long term storage.; Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MEK 1 antibody (left) or the same antibody preincubated with with blocking peptide (right))

Western Blot (WB)

(Western Blot analysis of extracts from HepG2 and PC 12 cells using MEK 1 antibody)

Related Product Information for anti-MEK1 antibody

MEK1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra-and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Product Categories/Family for anti-MEK1 antibody

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 2196704
• NCBI GeneID: 828713
• Molecular Weight: 34,087 Da
• NCBI Official Full Name: MEK1
• NCBI Official Symbol: MEK1
• NCBI Official Synonym Symbols: ATMEK1; F20B18.180; F20B18_180; MAP kinase/ ERK kinase 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MKK1; NMAPKK
• NCBI Protein Information: MAP kinase/ ERK kinase 1
• UniProt Protein Name: Mitogen-activated protein kinase kinase 1
• Protein Family: Meiosis-specific serine/threonine-protein kinase
• UniProt Gene Name: MKK1
• UniProt Synonym Gene Names: MEK1; AtMKK1; MAP kinase kinase 1

NCBI Description

Member of MAP Kinase Kinase. Likely functions in a stress-activated MAPK pathway. Can phosphorylate the MAPK AtMPK4, in response to stress. Gets phosphorylated by MEKK1 in response to wounding.

Uniprot Description

MEKK1, MKK1/MKK2 and MPK4/MPK6 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Activates by phosphorylation the downstream MPK4. Acts redundantly with MKK2. MKK1-MPK6 module mediates abscisic acid (ABA)-dependent CAT1 expression with H2O2 production and response to drought and salt stress. MKK1-MPK6 module is also involved in sugar signaling during the process of seed germination.