Rabbit Mek1 Polyclonal Antibody | anti-Mek1 antibody

Phospho-Mek1 antibody

Cat. Num. AAA835593

• Gene Names: MEK1; ATMEK1; F20B18.180; F20B18_180; MAP kinase/ ERK kinase 1; MEK1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MKK1; NMAPKK
• Applications: Immunofluorescence, Western Blot
• Purity: Phospho-Mek1 antibody was purified by affinity chromatography
• Synonyms: Mek1; Polyclonal Antibody; Phospho-Mek1 antibody; Polyclonal Phospho-Mek1; anti-Phospho-Mek1; ERK activator kinase 1/2; MAPK; Phospho-Mek 1; Dual specificity mitogen-activated protein kinase kinase 1/2; MEK 1/2; Phospho-Mek1; MAPKK 1/2; Erk; Phospho-Mek-1; MAP kinase kinase 1/2; MAPK/ERK kinase 1/2; anti-Mek1 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Phospho-Mek1 antibody was purified by affinity chromatography
• Form/Format: Supplied in PBS buffer containing 50% glycerol, 1% BSA, and 0.02% sodium azide
• Concentration: 500 ug/ml (varies by lot)
• Sequence Length: 354

• Applicable Applications for anti-Mek1 antibody: Immunofluorescence (IF), Western Blot (WB)
• Application Notes: WB: 1:200-1000
• Biological Significance: MAP kinase kinase 1, also known as mitogen activated protein kinase kinase, MAP kinase kinase, ERK kinase 1 or microtubule-associated protein 2 kinase, is a 43 kDa dual-specificity protein kinase that phosphorylates threonine and tyrosine residues on MAP kinases such as Erk 1 and 2. Mek1 and Mek2 are involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. Mek1 and Mek2 are activated by phosphorylation on serine 218 and 222 by serine-threonine kinase, Raf-1, which is part of the p21ras signal transduction pathway.
• Cross-Reactivity: Human, Mouse, Rat
• Immunogen: Phospho-Mek1 antibody was raised in Rabbit using synthetic peptide corresponding to amino acids surrounding Ser217/221 of human Mek1 as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-Mek1 antibody

Rabbit polyclonal Phospho-Mek1 antibody

Product Categories/Family for anti-Mek1 antibody

Proteases; Inhibitors; & Enzymes; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 2196704
• NCBI GeneID: 828713
• Molecular Weight: 34,087 Da
• NCBI Official Full Name: MEK1
• NCBI Official Symbol: MEK1
• NCBI Official Synonym Symbols: ATMEK1; F20B18.180; F20B18_180; MAP kinase/ ERK kinase 1; MEK1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MKK1; NMAPKK
• NCBI Protein Information: mitogen-activated protein kinase kinase 1
• UniProt Protein Name: Mitogen-activated protein kinase kinase 1
• Protein Family: Meiosis-specific serine/threonine-protein kinase
• UniProt Gene Name: MKK1
• UniProt Synonym Gene Names: MEK1; AtMKK1; MAP kinase kinase 1
• UniProt Entry Name: M2K1_ARATH

NCBI Description

Member of MAP Kinase Kinase. Likely functions in a stress-activated MAPK pathway. Can phosphorylate the MAPK AtMPK4, in response to stress. Gets phosphorylated by MEKK1 in response to wounding.

Uniprot Description

MEKK1, MKK1/MKK2 and MPK4/MPK6 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Activates by phosphorylation the downstream MPK4. Acts redundantly with MKK2. MKK1-MPK6 module mediates abscisic acid (ABA)-dependent CAT1 expression with H2O2 production and response to drought and salt stress. MKK1-MPK6 module is also involved in sugar signaling during the process of seed germination.