Rabbit anti-Human, Mouse MATER Polyclonal Antibody | anti-MATER antibody

MATER Antibody

Cat. Num. AAA9435442

• Gene Names: NLRP5; MATER; NALP5; PAN11; PYPAF8; CLR19.8
• Reactivity: Human, Mouse
• Applications: Immunocytochemistry
• Purity: Peptide affinity purified
• Synonyms: MATER; Polyclonal Antibody; MATER Antibody; CLR19.8 antibody; MATER antibody; Mater protein homolog antibody; Maternal antigen that embryos require antibody; NACHT; leucine rich repeat and PYD containing 5 antibody; LRR and PYD domains-containing protein 5 antibody; NALP5_HUMAN antibody; NLR family; pyrin domain containing 5 antibody; NLRP5 antibody; Nucleotide-binding oligomerization domain; leucine rich repeat and pyrin domain containing 5 antibody; PAN11 antibody; PYPAF8 antibody; anti-MATER antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Peptide affinity purified
• Form/Format: 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Applicable Applications for anti-MATER antibody: Immunocytochemistry (ICC)
• Application Notes: ICC: 1:200
• Immunogen: Peptide
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C.

Immunocytochemistry (ICC)

(ICC staining MATER in mouse blastocyst and 2-cell stage embryo (red). Cells were incubated overnight at 4��C with MATER rabbit pAb at 1/100 dilution (shown in red) and phalloidin antibody (shown in green).Nuclear DNA was labelled with DAPI (shown in blue).)

Related Product Information for anti-MATER antibody

NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis. NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals. Conserved oocyte-specific expression of NLRP5 is consistent among many mammalian species. As a member of the subcortical maternal complex (SCMC), it plays an essential role for zygotes to progress beyond the first embryonic cell divisions. NLRP5 also localizes to the nuclear envelope and mitochondria in germinal vesicle oocytes, suggesting a possible role in mitochondrial function.

Product Categories/Family for anti-MATER antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 158321897
• NCBI GeneID: 126206
• NCBI Accession #: NP_703148
• NCBI GenBank Nucleotide #: NM_153447.4
• UniProt Accession #: P59047; Q86W29; A8MTY4
• Molecular Weight: 134,342 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 5
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 5
• NCBI Official Symbol: NLRP5
• NCBI Official Synonym Symbols: MATER; NALP5; PAN11; PYPAF8; CLR19.8
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 5; mater protein homolog; maternal antigen that embryos require; NACHT, leucine rich repeat and PYD containing 5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 5
• Protein Family: Maternal B9.10 protein
• UniProt Gene Name: NLRP5
• UniProt Synonym Gene Names: MATER; NALP5
• UniProt Entry Name: NALP5_HUMAN

NCBI Description

The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

NLRP5: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. Belongs to the NLRP family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: protein complex; apical cortex; mitochondrion; nucleolus; cytosol

Molecular Function: ATP binding

Biological Process: regulation of RNA stability; organ morphogenesis; fertilization; cellular protein complex assembly; in utero embryonic development; regulation of protein stability; embryo implantation