Rabbit anti-Human MAGEA12 Polyclonal Antibody | anti-MAGEA12 antibody

MAGEA12 (Melanoma-associated Antigen 12, MAGE-12 Antigen, MAGE-12F Antigen, Cancer/Testis Antigen 1.12, CT1.12, MAGE12)

Cat. Num. AAA6004221

• Gene Names: MAGEA12; CT1.12; MAGE12
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: MAGEA12; Polyclonal Antibody; MAGEA12 (Melanoma-associated Antigen 12; MAGE-12 Antigen; MAGE-12F Antigen; Cancer/Testis Antigen 1.12; CT1.12; MAGE12); Anti -MAGEA12 (Melanoma-associated Antigen 12; anti-MAGEA12 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human MAGEA12.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% sodium azide.

• Applicable Applications for anti-MAGEA12 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1000; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to aa96-108 of human MAGEA12 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Testis (formalin-fixed, paraffin-embedded) stained with MAGEA12 antibody at 5ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-MAGEA12 antibody

MAGEA12 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This gene is expressed in various tumors and tumor cell lines from different tissue origins, but not detected in normal tissues, except testis. The function of this gene is unknown. This and other MAGE genes form a gene cluster at chromosome Xq28 region.

Product Categories/Family for anti-MAGEA12 antibody

Antibodies; Abs to Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 261878485
• NCBI GeneID: 4111
• NCBI Accession #: NP_001159859.1
• NCBI GenBank Nucleotide #: NM_001166387.1
• UniProt Accession #: P43365; Q9NSD3
• Molecular Weight: 34,836 Da
• NCBI Official Full Name: melanoma-associated antigen 12
• NCBI Official Synonym Full Names: melanoma antigen family A, 12
• NCBI Official Symbol: MAGEA12
• NCBI Official Synonym Symbols: CT1.12; MAGE12
• NCBI Protein Information: melanoma-associated antigen 12; MAGE12F antigen; cancer/testis antigen 1.12; cancer/testis antigen family 1, member 12
• UniProt Protein Name: Melanoma-associated antigen 12
• Protein Family: Melanoma-associated antigen
• UniProt Gene Name: MAGEA12
• UniProt Synonym Gene Names: MAGE12; CT1.12
• UniProt Entry Name: MAGAC_HUMAN

NCBI Description

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]

Uniprot Description

MAGEA12: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: Xq28