Rabbit anti-Human MAGEA1 / MAGE 1 Polyclonal Antibody | anti-MAGEA1 antibody

Rabbit Polyclonal (IgG) to Human MAGEA1 / MAGE 1

Cat. Num. AAA244873

• Gene Names: MAGEA1; CT1.1; MAGE1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: MAGEA1 / MAGE 1; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human MAGEA1 / MAGE 1; Anti-MAGEA1 / MAGE 1 Antibody (aa260-309) IHC-plus; MAGEA1; Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGE-1 antigen; MAGE1A; Melanoma antigen family A 1; Melanoma antigen MAGE-1; MAGE 1; MAGE1; Melanoma-associated antigen 1; Human MAGEA1; anti-MAGEA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MAGE-1 Antibody detects endogenous levels of total MAGE-1 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 309

• Applicable Applications for anti-MAGEA1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:10000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human MAGE-1 (aa260-309).
• Immunogen: MAGEA1 / MAGE 1 antibody was raised against synthetic peptide from human MAGE-1 (aa260-309).
• Antigen Modification: aa260-309
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-MAGEA1 / MAGE 1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(Western blot of extracts from HepG2 cells, using MAGE-1 Antibody. The lane on the right is treated with the synthesized peptide.)

Related Product Information for anti-MAGEA1 antibody

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.

NCBI and Uniprot Product Information

• NCBI GI #: 148276977
• NCBI GeneID: 4100
• NCBI Accession #: NP_004979.3
• NCBI GenBank Nucleotide #: NM_004988.4
• UniProt Accession #: P43355; O00346; B2RC81; AAB33086
• Molecular Weight: 34,342 Da
• NCBI Official Full Name: melanoma-associated antigen 1
• NCBI Official Synonym Full Names: melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
• NCBI Official Symbol: MAGEA1
• NCBI Official Synonym Symbols: CT1.1; MAGE1
• NCBI Protein Information: melanoma-associated antigen 1; antigen MZ2-E; MAGE-1 antigen; melanoma antigen MAGE-1; cancer/testis antigen 1.1; melanoma antigen family A 1; melanoma-associated antigen MZ2-E; cancer/testis antigen family 1, member 1
• UniProt Protein Name: Melanoma-associated antigen 1
• Protein Family: Melanoma-associated antigen
• UniProt Gene Name: MAGEA1
• UniProt Synonym Gene Names: MAGE1; MAGE1A; CT1.1
• UniProt Entry Name: MAGA1_HUMAN

NCBI Description

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

Uniprot Description

MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; histone deacetylase binding

Biological Process: transcription, DNA-dependent; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter