Rabbit anti-Human, Mouse MAGEA1 Polyclonal Antibody | anti-MAGEA1 antibody

MAGEA1 Rabbit Polyclonal

Cat. Num. AAA7601166

• Gene Names: MAGEA1; CT1.1; MAGE1
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Purification: Immunogen affinity purified; Purity: > = 95% as determined by SDS-PAGE
• Synonyms: MAGEA1; Polyclonal Antibody; MAGEA1 Rabbit Polyclonal; MAGE1; MAGE1A; anti-MAGEA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purification: Immunogen affinity purified; Purity: > = 95% as determined by SDS-PAGE
• Form/Format: Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Sequence Length: 309

• Applicable Applications for anti-MAGEA1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:100
• Immunogen: Melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
• Preparation and Storage: -20 degree C for 12 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer using MBS7601166 (MAGEA1 antibody) at dilution of 1:100)

Western Blot (WB)

(A375 cells were subjected to SDS PAGE followed by western blot with MBS7601166 (MAGEA1 antibody) at dilution of 1:1000)

Related Product Information for anti-MAGEA1 antibody

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.

NCBI and Uniprot Product Information

• NCBI GI #: 148276977
• NCBI GeneID: 4100
• NCBI Accession #: NP_004979.3
• NCBI GenBank Nucleotide #: NM_004988.4
• UniProt Accession #: P43355; O00346; B2RC81; AAB33086
• Molecular Weight: 45 kDa
• NCBI Official Full Name: melanoma-associated antigen 1
• NCBI Official Synonym Full Names: MAGE family member A1
• NCBI Official Symbol: MAGEA1
• NCBI Official Synonym Symbols: CT1.1; MAGE1
• NCBI Protein Information: melanoma-associated antigen 1
• UniProt Protein Name: Melanoma-associated antigen 1
• Protein Family: Melanoma-associated antigen
• UniProt Gene Name: MAGEA1
• UniProt Synonym Gene Names: MAGE1; MAGE1A; CT1.1
• UniProt Entry Name: MAGA1_HUMAN

NCBI Description

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

Uniprot Description

MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; nucleus; plasma membrane

Molecular Function: histone deacetylase binding; protein binding

Biological Process: negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent