Western Blot (WB)
(LZTS1 Antibody (N-term) western blot analysis in A2058 cell line and mouse brain tissue lysates (35ug/lane).This demonstrates the LZTS1 antibody detected the LZTS1 protein (arrow).)
Rabbit anti-Human, mouse LZTS1 Polyclonal Antibody | anti-LZTS1 antibody
LZTS1 Antibody (N-term)
Western Blot (WB)
(LZTS1 Antibody (N-term) western blot analysis in A2058 cell line and mouse brain tissue lysates (35ug/lane).This demonstrates the LZTS1 antibody detected the LZTS1 protein (arrow).)
Western Blot (WB)
(LZTS1 Antibody (N-term) western blot analysis in A2058 cell line and mouse brain tissue lysates (35ug/lane).This demonstrates the LZTS1 antibody detected the LZTS1 protein (arrow).)
ubiquitously expressed in normal tissues. In uveal melanomas,
expression of this protein is silenced in rapidly metastasizing and
metastatic tumor cells but has normal expression in slowly
metastasizing or nonmetastasizing tumor cells. This protein may
have a role in cell-cycle control by interacting with the
Cdk1/cyclinB1 complex. This gene is located on chromosomal region
8p22. Loss of heterozygosity (LOH) in the 8p arm is a common
characteristic of many types of cancer.
Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010)
Califano, D., et al. J. Cell. Physiol. 222(2):382-386(2010)
Shyn, S.I., et al. Mol. Psychiatry (2009) In press :
Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
Uniprot Description
LZTS1: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. Defects in LZTS1 may be a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Belongs to the LZTS family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; Transcription factor
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: postsynaptic membrane; postsynaptic density; cytoplasm; apical plasma membrane; dendritic spine; dendritic shaft; cell junction
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: negative regulation of macroautophagy; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of dendrite morphogenesis; cell cycle
Disease: Esophageal Cancer
Research Articles on LZTS1
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Product Notes
The LZTS1 lzts1 (Catalog #AAA9204663) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 77-105. The LZTS1 Antibody (N-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LZTS1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the LZTS1 lzts1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LZTS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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