Rabbit anti-Human LZTS1 Polyclonal Antibody | anti-LZTS1 antibody

LZTS1, NT (LZTS1, FEZ1, Leucine zipper putative tumor suppressor 1, F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1) (Biotin)

Cat. Num. AAA6317848

• Gene Names: LZTS1; F37; FEZ1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LZTS1; Polyclonal Antibody; NT (LZTS1; FEZ1; Leucine zipper putative tumor suppressor 1; F37/esophageal cancer-related gene-coding leucine-zipper motif; Fez1) (Biotin); Fez1; anti-LZTS1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-LZTS1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: LZTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human LZTS1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(LZTS1 Antibody (N-term) western blot analysis in A2058 cell line and mouse brain tissue lysates (35ug/lane).This demonstrates the LZTS1 antibody detected the LZTS1 protein (arrow).)

Related Product Information for anti-LZTS1 antibody

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.

Product Categories/Family for anti-LZTS1 antibody

Antibodies; Cancer Markers

References

Olson, J.E., et al. Breast Cancer Res. Treat. (2010). In press: Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010). Califano, D., et al. J. Cell. Physiol. 222(2):382-386(2010). Shyn, S.I., et al. Mol. Psychiatry (2009). In press: Canova, C., et al. Cancer Res. 69(7):2956-2965(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 10440566
• NCBI GeneID: 11178
• NCBI Accession #: NP_066300.1
• NCBI GenBank Nucleotide #: NM_021020.2
• UniProt Accession #: Q9Y250; Q9Y5V7; Q9Y5V8; Q9Y5V9; Q9Y5W0; Q9Y5W1; Q9Y5W2; D3DSQ6
• Molecular Weight: 66,613 Da
• NCBI Official Full Name: leucine zipper putative tumor suppressor 1
• NCBI Official Synonym Full Names: leucine zipper, putative tumor suppressor 1
• NCBI Official Symbol: LZTS1
• NCBI Official Synonym Symbols: F37; FEZ1
• NCBI Protein Information: leucine zipper putative tumor suppressor 1; F37/Esophageal cancer-related gene-coding leucine-zipper motif
• UniProt Protein Name: Leucine zipper putative tumor suppressor 1
• Protein Family: Leucine zipper putative tumor suppressor
• UniProt Gene Name: LZTS1
• UniProt Synonym Gene Names: FEZ1
• UniProt Entry Name: LZTS1_HUMAN

NCBI Description

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]