Western Blot/Blotting
(Western blot analysis)
Rabbit anti-Human Sphingosine 1 Phosphate Receptor 5 CT (EDG-8) Polyclonal Antibody | anti-EDG-8 antibody
Sphingosine 1 Phosphate Receptor 5 CT (EDG-8)
Western Blot/Blotting
(Western blot analysis)
Western Blot/Blotting
(Western blot analysis)
NCBI and Uniprot Product Information
NCBI Description
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Uniprot Description
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G12 subclass of heteromeric G-proteins
By similarity. May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. Ref.10
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. Ref.1 Ref.3 Ref.9
Developmental stage: At 24 weeks of gestation, fragments of radial glial fibers are positive within the cortical plate and subplate of allocortical areas. These positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain immunolabeled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear; instead positive transitional stages between radial glia and astrocytes were found. Ref.10
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Research Articles on EDG-8
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Product Notes
The EDG-8 s1pr5 (Catalog #AAA395666) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Sphingosine 1 Phosphate Receptor 5 CT (EDG-8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Sphingosine 1 Phosphate Receptor 5 CT (EDG-8) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the EDG-8 s1pr5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sphingosine 1 Phosphate Receptor 5 CT (EDG-8), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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