Rabbit Lysine, Acetylated Polyclonal Antibody
Lysine, Acetylated (Acetyl-Lysine) (Biotin)
Applications
ELISA, Western Blot, Immunoprecipitation, Immunofluorescence, immunoassay, Radioimmunoassay
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
Lysine; Acetylated; Polyclonal Antibody; Acetylated (Acetyl-Lysine) (Biotin); Anti -Lysine; anti-Lysine; Acetylated antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes proteins containing acetylated lysine residues in SDS-PAGE immunoblots. Species Crossreactivity: Acetylated lysine residues. No reaction to non-acetylated proteins.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH7, 50% glycerol.
Applicable Applications for anti-Lysine, Acetylated antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Radioimmunoassay (RIA)
Application Notes
Suitable for use in RIA, Immunofluorescence, ELISA, Western Blot and Immunoprecipitation.
Dilution: Western Blot:1:250 detects the acetylated histone from TSA-treated mouse spleen cells.
Dilution: Western Blot:1:250 detects the acetylated histone from TSA-treated mouse spleen cells.
Immunogen
Acetylated KLH.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-Lysine, Acetylated antibody
Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine N -acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3). The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases (4), and HDACs have become promising targets for anti- cancer drugs currently in development (5).
Product Categories/Family for anti-Lysine, Acetylated antibody
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Product Notes
The Lysine, Acetylated (Catalog #AAA647228) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Lysine, Acetylated can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Radioimmunoassay (RIA). Suitable for use in RIA, Immunofluorescence, ELISA, Western Blot and Immunoprecipitation. Dilution: Western Blot:1:250 detects the acetylated histone from TSA-treated mouse spleen cells. Researchers should empirically determine the suitability of the Lysine, Acetylated for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lysine, Acetylated, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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