Rabbit anti-Human, Mouse LSM10 Polyclonal Antibody | anti-LSM10 antibody

LSM10 Polyclonal Antibody

Cat. Num. AAA2560657

• Gene Names: LSM10; MST074; MSTP074
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: LSM10; Polyclonal Antibody; LSM10 Polyclonal Antibody; LSM 10; LSM10 U7 small nuclear RNA associated; MGC15749; MST074; MSTP074; U7 snRNA associated Sm like protein LSm10; U7 snRNP specific Sm like protein LSM10; anti-LSM10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.9mg/mL (varies by lot)
• Sequence Length: 123

• Applicable Applications for anti-LSM10 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:300; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human LSM10
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using LSM10 Polyclonal Antibody at dilution of 1:50(×200))

Related Product Information for anti-LSM10 antibody

LSm10 (U7 snRNA-associated Sm-like protein LSm10) is a nuclear protein that belongs to the snRNP (small nuclear ribonucleoproteins) Sm protein family. The survival of motor neurons (SMN) complex mediates the assembly of snRNPs involved in splicing and histone RNA processing. A crucial step in this process is the binding of Sm proteins onto the SMN protein. LSm10 and LSm11, mammalian homologs of the yeast Sm proteins D1 and D2, are important for U7 snRNP function and subcellular localization. U7 snRNP is an RNA molecule involved in the splicing of animal histone pre-mRNAs. Lsm10 and Lsm11 also associate with pICln (Chloride ion current inducer protein), which interacts with Sm proteins to inhibit their assembly on U RNA. LSm10 interactions with U7 snRNA and pICln may provide the means for using modified U7 snRNA derivatives to alter specific pre-mRNA splicing events, potentially leading to advances in antisense gene therapy.

Product Categories/Family for anti-LSM10 antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 14249632
• NCBI GeneID: 84967
• NCBI Accession #: NP_116270.1; BC007623
• NCBI GenBank Nucleotide #: NP_116270.1
• UniProt Accession #: Q969L4
• NCBI Official Full Name: U7 snRNA-associated Sm-like protein LSm10
• NCBI Official Synonym Full Names: LSM10, U7 small nuclear RNA associated
• NCBI Official Symbol: LSM10
• NCBI Official Synonym Symbols: MST074; MSTP074
• NCBI Protein Information: U7 snRNA-associated Sm-like protein LSm10
• UniProt Protein Name: U7 snRNA-associated Sm-like protein LSm10
• Protein Family: U7 snRNA-associated Sm-like protein
• UniProt Gene Name: LSM10
• UniProt Entry Name: LSM10_HUMAN

Uniprot Description

LSM10: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. Belongs to the snRNP Sm proteins family.

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; Cajal body; nucleus

Molecular Function: protein binding

Biological Process: transcription from RNA polymerase II promoter; RNA splicing; histone mRNA metabolic process; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription