Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using KIF14 Antibody at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))
Rabbit anti-Human KIF14 Polyclonal Antibody | anti-KIF14 antibody
KIF14 Antibody
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using KIF14 Antibody at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using KIF14 Antibody at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Uniprot Description
KIF14: Plays an essential role in cytokinesis. Belongs to the kinesin-like protein family.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: cytosol; kinesin complex; membrane; microtubule; midbody; plasma membrane; spindle midzone
Molecular Function: ATP binding; ATPase activity; microtubule binding; microtubule motor activity; PDZ domain binding; plus-end-directed microtubule motor activity; protein binding; protein kinase binding; tubulin binding
Biological Process: activation of protein kinase activity; cell proliferation in forebrain; cerebellar cortex development; cerebellar granular layer structural organization; cerebellar Purkinje cell layer structural organization; cerebral cortex development; cytoskeleton-dependent intracellular transport; establishment of protein localization; hippocampus development; microtubule depolymerization; microtubule-based movement; mitotic metaphase plate congression; negative regulation of apoptosis; negative regulation of integrin activation; negative regulation of neuron apoptosis; olfactory bulb development; positive regulation of cell proliferation; positive regulation of cytokinesis; proteasomal ubiquitin-dependent protein catabolic process; regulation of cell adhesion; regulation of cell growth; regulation of cell migration; regulation of G2/M transition of mitotic cell cycle; regulation of myelination; regulation of neuron apoptosis; regulation of Rap protein signal transduction; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Disease: Meckel Syndrome 12
Research Articles on KIF14
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Product Notes
The KIF14 kif14 (Catalog #AAA9417160) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KIF14 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KIF14 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1: 20-100. Researchers should empirically determine the suitability of the KIF14 kif14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KIF14, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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