Western Blot (WB)
(KIAA0427 antibody (MBS5300114) used at 1 ug/ml to detect target protein.)
Rabbit anti-Human, Rat KIAA0427 Polyclonal Antibody | anti-KIAA0427 antibody
KIAA0427 antibody
Western Blot (WB)
(KIAA0427 antibody (MBS5300114) used at 1 ug/ml to detect target protein.)
Western Blot (WB)
(KIAA0427 antibody (MBS5300114) used at 1 ug/ml to detect target protein.)
NCBI and Uniprot Product Information
Uniprot Description
CTIF: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). Belongs to the CTIF family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: perinuclear region of cytoplasm; cytoplasm
Molecular Function: protein binding; RNA binding
Biological Process: mRNA catabolic process, nonsense-mediated decay; regulation of translational initiation
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Product Notes
The KIAA0427 ctif (Catalog #AAA5300114) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KIAA0427 antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KIAA0427 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1 ug/ml. Researchers should empirically determine the suitability of the KIAA0427 ctif for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KIAA0427, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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