Rabbit anti-Mouse, Rat KCNMB2 Polyclonal Antibody | anti-KCNMB2 antibody

KCNMB2 Polyclonal Antibody

Cat. Num. AAA9130788

• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: KCNMB2; Polyclonal Antibody; KCNMB2 Polyclonal Antibody; anti-KCNMB2 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 235

• Applicable Applications for anti-KCNMB2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500 - 1:2000
• Immunogen: Recombinant protein of human KCNMB2
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using KCNMB2 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 30s.)

Related Product Information for anti-KCNMB2 antibody

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described.

Product Categories/Family for anti-KCNMB2 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 46396054
• NCBI GeneID: 10242
• UniProt Accession #: Q9Y691
• Molecular Weight: 27kDa
• NCBI Official Full Name: Calcium-activated potassium channel subunit beta-2
• NCBI Official Synonym Full Names: potassium calcium-activated channel subfamily M regulatory beta subunit 2
• NCBI Official Symbol: KCNMB2
• NCBI Protein Information: calcium-activated potassium channel subunit beta-2
• UniProt Protein Name: Calcium-activated potassium channel subunit beta-2
• Protein Family: Calcium-activated potassium channel
• UniProt Gene Name: KCNMB2
• UniProt Synonym Gene Names: BKbeta2; Hbeta2

NCBI Description

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]

Uniprot Description

KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q26.32

Cellular Component: integral to plasma membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: calcium-activated potassium channel activity; ion channel inhibitor activity; potassium channel regulator activity

Biological Process: detection of calcium ion; generation of action potential; potassium ion transport; regulation of action potential; regulation of vasoconstriction; synaptic transmission