Rabbit anti-Human KCNK6 Polyclonal Antibody | anti-KCNK6 antibody

KCNK6, CT (KCNK6, TOSS, TWIK2, Potassium channel subfamily K member 6, Inward rectifying potassium channel protein TWIK-2, TWIK-originated similarity sequence) (FITC)

Cat. Num. AAA6312657

• Gene Names: KCNK6; TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNK6; Polyclonal Antibody; CT (KCNK6; TOSS; TWIK2; Potassium channel subfamily K member 6; Inward rectifying potassium channel protein TWIK-2; TWIK-originated similarity sequence) (FITC); TWIK-originated similarity sequence; anti-KCNK6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-KCNK6 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human KCNK6.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNK6 Antibody (C-term) western blot analysis in MDA-MB468 cell line lysates (35ug/lane).This demonstrates the KCNK6 antibody detected the KCNK6 protein (arrow).)

Related Product Information for anti-KCNK6 antibody

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq].

Product Categories/Family for anti-KCNK6 antibody

Antibodies; Ion Channel

References

Sebastiani, P., et al. Am. J. Hematol. 85(1):29-35(2010). Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008). Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005). Mhatre, A.N., et al. J. Neurosci. Res. 75(1):25-31(2004). Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 4758624
• NCBI GeneID: 9424
• NCBI Accession #: NP_004814.1
• NCBI GenBank Nucleotide #: NM_004823.1
• UniProt Accession #: Q9Y257; Q9HB47
• Molecular Weight: 33,747 Da
• NCBI Official Full Name: potassium channel subfamily K member 6
• NCBI Official Synonym Full Names: potassium channel, subfamily K, member 6
• NCBI Official Symbol: KCNK6
• NCBI Official Synonym Symbols: TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2
• NCBI Protein Information: potassium channel subfamily K member 6; K2P6.1 potassium channel; TWIK-originated similarity sequence; TWIK-originated sodium similarity sequence; inward rectifying potassium channel protein TWIK-2
• UniProt Protein Name: Potassium channel subfamily K member 6
• Protein Family: Potassium channel subfamily
• UniProt Gene Name: KCNK6
• UniProt Synonym Gene Names: TOSS; TWIK2
• UniProt Entry Name: KCNK6_HUMAN

NCBI Description

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

Uniprot Description

KCNK6: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: voltage-gated potassium channel complex; plasma membrane

Molecular Function: inward rectifier potassium channel activity

Biological Process: synaptic transmission; negative regulation of systemic arterial blood pressure; regulation of resting membrane potential; potassium ion transport