Rabbit anti-Human KATNA1 Polyclonal Antibody | anti-KATNA1 antibody

KATNA1 (Katanin p60 ATPase-containing Subunit A1, Katanin p60 Subunit A1, p60 Katanin) (Biotin)

Cat. Num. AAA6383445

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KATNA1; Polyclonal Antibody; KATNA1 (Katanin p60 ATPase-containing Subunit A1; Katanin p60 Subunit A1; p60 Katanin) (Biotin); anti-KATNA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human KATNA1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-KATNA1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human KATNA1, aa1-311 (AAH50428.1).
• Immunogen Sequence: MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSGMRP
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of KATNA1 expression in transfected 293T cell line by KATNA1 polyclonal antibody. Lane 1: KATNA1 transfected lysate (35.3kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-KATNA1 antibody

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Product Categories/Family for anti-KATNA1 antibody

Antibodies; Enzymes; ATPase

NCBI and Uniprot Product Information

• NCBI GI #: 29792186
• NCBI GeneID: 11104
• Molecular Weight: 35,319 Da
• NCBI Official Full Name: Homo sapiens katanin p60 (ATPase-containing) subunit A 1, mRNA
• NCBI Official Synonym Full Names: katanin p60 (ATPase containing) subunit A 1
• NCBI Official Symbol: KATNA1
• NCBI Protein Information: katanin p60 ATPase-containing subunit A1; KATNA1; katanin p60 (ATPase-containing) subunit A 1; katanin p60 subunit A1; p60 katanin

NCBI Description

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]