Rabbit anti-Human JIP3 Polyclonal Antibody | anti-JIP3 antibody

JIP3 Conjugated Antibody

Cat. Num. AAA9444971

• Gene Names: MAPK8IP3; syd; JIP3; SYD2; JSAP1
• Reactivity: Human
• Applications: Most Applications
• Synonyms: JIP3; Polyclonal Antibody; JIP3 Conjugated Antibody; C-jun-amino-terminal kinase interacting protein 3; JIP-3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; anti-JIP3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total JIP3 protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-JIP3 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthesized peptide derived from internal of human JIP3.
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-JIP3 antibody

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins by similarity. UniProtKB Q9ESN9

NCBI and Uniprot Product Information

• NCBI GI #: 94557295
• NCBI GeneID: 23162
• NCBI Accession #: NP_001035529.1
• NCBI GenBank Nucleotide #: NM_001040439.1
• UniProt Accession #: Q9UPT6; Q96RY4; Q9H4I4; Q9H7P1; Q9NUG0; A2A2B3; A7E2B3
• Molecular Weight: 147,457 Da
• NCBI Official Full Name: C-Jun-amino-terminal kinase-interacting protein 3 isoform 2
• NCBI Official Synonym Full Names: mitogen-activated protein kinase 8 interacting protein 3
• NCBI Official Symbol: MAPK8IP3
• NCBI Official Synonym Symbols: syd; JIP3; SYD2; JSAP1
• NCBI Protein Information: C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK-interacting protein 3; JNK/SAPK-associated protein-1; JNK MAP kinase scaffold protein 3; homolog of Drosophila Sunday driver 2; C-jun-amino-terminal kinase interacting protein 3; JNK/stress-act
• UniProt Protein Name: C-Jun-amino-terminal kinase-interacting protein 3
• Protein Family: Putative uncharacterized protein
• UniProt Gene Name: MAPK8IP3
• UniProt Synonym Gene Names: JIP3; KIAA1066; JIP-3
• UniProt Entry Name: JIP3_HUMAN

NCBI Description

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

JIP3: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: Golgi membrane; smooth endoplasmic reticulum; dendrite; cytoplasm; axolemma

Molecular Function: JUN kinase binding; MAP-kinase scaffold activity; receptor signaling complex scaffold activity; mitogen-activated protein kinase kinase binding; kinesin binding; mitogen-activated protein kinase kinase kinase binding

Biological Process: vesicle-mediated transport; axon guidance; protein localization; regulation of gene expression; in utero embryonic development; forebrain development; respiratory gaseous exchange; positive regulation of neuron differentiation; alveolus development; regulation of JNK cascade; activation of JNK activity; post-embryonic development