Rabbit anti-Mouse, Rat IP3 Receptor-1 Polyclonal Antibody | anti-IP3R antibody

Anti-IP3 Receptor-1 Antibody

Cat. Num. AAA4159138

• Reactivity: Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified on immobilized rProtein A.
• Synonyms: IP3 Receptor-1; Polyclonal Antibody; Anti-IP3 Receptor-1 Antibody; anti-IP3R antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human, mouse-identical.
• Purity/Purification: Purified on immobilized rProtein A.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)

• Applicable Applications for anti-IP3R antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: Rat brain membranes (1:1000-1:2000); IHC: Mouse brain section.
• Immunogen: Peptide(C)RIGL LGHPP HMNVN PQQPA corresponding to residues 2732-2750 of rat IP3R1 (Accession P29994).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Testing Data

Related Product Information for anti-IP3R antibody

Inositol 1, 4, 5-triphosphate (IP3) serves as a second messenger for many neurotransmitters, hormones and growth factors.1 The binding of IP3 to its receptor (IP3R), which is a ligand gated Ca2+ channel, located predominantly at the endoplasmic reticulum, results in a rapid release of Ca2+ from intracellular stores.1 To date, three known isoforms of IP3R are known (designated IP3R1, IP3R2, and IP3R3) that can work as homotetramers or hetrotetramers. All three receptors have six transmembrane domains and a pore domain between TM5 and TM6. The N-terminus as well as the C-terminus are facing the cytoplasm. Each IP3R consists of an N-terminal ligand binding domain (LBD) and a C-terminal domain which is linked by a long regulatory domain. The C-terminus is constitutively active, suggesting that the regulatory domain is required in order to maintain the suppression of channel activity.2 IP3R1 is one of the most important channels responsible for Ca2+ release from intracellular stores and was shown to be the predominant isoform expressed in the central nervous system. IP3R1 is a pivotal player in many neuronal functions such as neuronal plasticity, neurite extension and others.3