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Testing Data

Rabbit anti-Human, Rat KCa2.3 Polyclonal Antibody | anti-KCa2.3 antibody

Anti-KCa2.3 (C-Term) (SK3) Antibody

Reactivity
Human, Rat
Applications
Western Blot
Purity
Affinity Purified On Immobilized Antigen
Synonyms
KCa2.3; Polyclonal Antibody; Anti-KCa2.3 (C-Term) (SK3) Antibody; K Ca2-3; anti-KCa2.3 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Rat
Clonality
Polyclonal
Specificity
Rat, mouse, pig-identical
Purity/Purification
Affinity Purified On Immobilized Antigen
Form/Format
Liquid; PBS, pH 7.4 with 0.05% sodium azide.
Concentration
1ug/ul (varies by lot)
Applicable Applications for anti-KCa2.3 antibody
Western Blot (WB)
Application Notes
WB: Rat brain membranes (1:200)
Immunogen
Peptide (C)KQIGSLESKLEHLTAS, corresponding to amino acid residues 659-674 of human KCa2.3 (Accession Q9UGI6).
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Testing Data
Related Product Information for anti-KCa2.3 antibody
Small conductance Ca2+-activated K+ Channel 3, SK3, SKCa3, KCNN3 KCa2.3 is a member of the Ca2+-activated K+ channels family with small conductance that includes KCa2.1 (SK1) and KCa2.2 (SK2). The channel is voltage insensitive and is activated by intracellular Ca2+ in the submicromolar range. It has, though, a similar topology to that of voltage-dependent K+ channels (Kv channels), that is six transmembrane domains and intracellular N-and C-termini. The functional channel of all the KCa2 family members is a multimeric protein composed of four pore-forming subunits. KCa2 channels are extremely sensitive to the levels of intracellular Ca2+ and concentrations as low as 300-700 nM can open the channels very rapidly (5-15 ms). Hence, the KCa2 channels are highly sensitive and fast Ca2+ sensors resembling other known Ca2+-binding proteins. This type of Ca2+-dependent activation is achieved by the constitutive binding of the KCa2 channels to calmodulin, a highly expressed Ca2+-binding protein via a calmodulin-binding domain situated at the cytoplasmic C-termini. Pharmacologically, the KCa2 channels are the only known targets of the bee venom toxin Apamin, with KCa2.1 being the less sensitive, KCa2.2 the most sensitive and KCa2.3 showing intermediate sensitivity. KCa2.3 is predominantly expressed in the nervous system although expression in endothelial cells, heart and liver have been described. KCa2.3 is known to be involved in the regulation of neuronal excitability. They do so mainly via a phenomenon known as afterhyperpolarization in which KCa2 channels open in response to increased intracellular Ca2+ concentrations that result from the entry of extracellular Ca2+ through voltage-dependent Ca2+ channels during action potentials. In this way, KCa2 channels effectively form a Ca2+-mediated feedback loop. KCa2.3 is involved in the control of firing rate and subsequent dopamine secretion from midbrain dopaminergic neurons. Since malfunction of these neurons is involved in several pathological disorders such as Parkinson

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Product Notes

The KCa2.3 (Catalog #AAA4159224) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-KCa2.3 (C-Term) (SK3) Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KCa2.3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: Rat brain membranes (1:200). Researchers should empirically determine the suitability of the KCa2.3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCa2.3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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