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Western Blot (WB) (Western Blot (WB) analysis of Integrin beta3 (S778) pAb at 1:500 dilutionLane1:BV2 whole cell lysate (40ug) Lane2:RAW264. 7 whole cell lysate (40ug) Lane3:The Uterus tissue lysate of Rat (40ug) Lane4:THP-1 whole cell lysate (40ug) Lane5:A549 whole cell lysate (40ug) Lane6:PC3 whole cell lysate (40ug) Lane7:U-87MG whole cell lysate (40ug))

Rabbit Integrin beta3 Polyclonal Antibody | anti-S778 antibody

Integrin beta3 (S778) Polyclonal Antibody

Gene Names
ITGB3; GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
Integrin beta3; Polyclonal Antibody; Integrin beta3 (S778) Polyclonal Antibody; Integrin beta-3; Platelet membrane glycoprotein IIIa; Short name=GPIIIa; CD_antigen=CD61; ITGB3; GP3A; CD61; GPIIIa; anti-S778 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Integrin beta3 (S778) polyclonal antibody detects endogenous levels of Integrin beta3 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
788
Applicable Applications for anti-S778 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:1000
IHC: 1:50-1:200
Immunogen
Synthetic peptide, corresponding to amino acids 751-800 of Human Integrin beta3.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Integrin beta3 (S778) pAb at 1:500 dilutionLane1:BV2 whole cell lysate (40ug) Lane2:RAW264. 7 whole cell lysate (40ug) Lane3:The Uterus tissue lysate of Rat (40ug) Lane4:THP-1 whole cell lysate (40ug) Lane5:A549 whole cell lysate (40ug) Lane6:PC3 whole cell lysate (40ug) Lane7:U-87MG whole cell lysate (40ug))

Western Blot (WB) (Western Blot (WB) analysis of Integrin beta3 (S778) pAb at 1:500 dilutionLane1:BV2 whole cell lysate (40ug) Lane2:RAW264. 7 whole cell lysate (40ug) Lane3:The Uterus tissue lysate of Rat (40ug) Lane4:THP-1 whole cell lysate (40ug) Lane5:A549 whole cell lysate (40ug) Lane6:PC3 whole cell lysate (40ug) Lane7:U-87MG whole cell lysate (40ug))

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of Integrin beta3 (S778) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)

Immunohistochemistry (IHC) (Immunohistochemistry (IHC) analyzes of Integrin beta3 (S778) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)
Related Product Information for anti-S778 antibody
Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits. The 16alpha and 8beta subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 87, 110kDa
NCBI Official Full Name
integrin beta-3
NCBI Official Synonym Full Names
integrin subunit beta 3
NCBI Official Symbol
ITGB3
NCBI Official Synonym Symbols
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
NCBI Protein Information
integrin beta-3
UniProt Protein Name
Integrin beta-3
UniProt Gene Name
ITGB3
UniProt Synonym Gene Names
GP3A; GPIIIa
UniProt Entry Name
ITB3_HUMAN

NCBI Description

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

Uniprot Description

ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: filopodium membrane; platelet alpha granule membrane; focal adhesion; cell surface; microvillus membrane; integral to plasma membrane; plasma membrane; melanosome; integrin complex; nucleus; receptor complex

Molecular Function: identical protein binding; protein binding; protease binding; extracellular matrix binding; vascular endothelial growth factor receptor 2 binding; fibronectin binding; platelet-derived growth factor receptor binding; protein disulfide isomerase activity; cell adhesion molecule binding; receptor activity

Biological Process: negative regulation of lipid transport; axon guidance; entry of virus into host cell; extracellular matrix organization and biogenesis; protein folding; wound healing; cell-matrix adhesion; smooth muscle cell migration; mesodermal cell differentiation; negative chemotaxis; positive regulation of vascular endothelial growth factor receptor signaling pathway; platelet degranulation; cell-substrate junction assembly; cell growth; cell adhesion; integrin-mediated signaling pathway; platelet activation; regulation of bone resorption; cell migration; negative regulation of lipoprotein metabolic process; angiogenesis involved in wound healing; cell-substrate adhesion; heterotypic cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; tube development; blood coagulation; vascular endothelial growth factor receptor signaling pathway; leukocyte migration

Disease: Myocardial Infarction, Susceptibility To; Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16

Research Articles on S778

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Product Notes

The S778 itgb3 (Catalog #AAA3004096) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Integrin beta3 (S778) Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin beta3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:1000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the S778 itgb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Integrin beta3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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