Rabbit anti-Human HTRA3 Polyclonal Antibody | anti-HTRA3 antibody

HTRA3 Conjugated Antibody

Cat. Num. AAA9447803

• Gene Names: PIWIL3; HIWI3
• Reactivity: Human
• Applications: Most Applications
• Synonyms: HTRA3; Polyclonal Antibody; HTRA3 Conjugated Antibody; Prsp; Tasp; anti-HTRA3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total HTRA3 protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-HTRA3 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human HtrA serine peptidase 3
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-HTRA3 antibody

HtrA3, also known as PRSP (pregnancy-related serine protease), is a 453 amino acid secreted protein that contains one PDZ domain, one Kazal-like domain and one IGFBP N-terminal domain. Widely expressed with particularly high expression in ovary, heart, placenta and bladder, HtrA3 functions as a probable serine protease that is thought to play an important role in placental development. HtrA3 is downregulated in ovarian tumors, suggesting an alternative role in tumor suppression. HtrA3 exists as two alternatively spliced isoforMouse, designated short and long. The gene encoding HtrA3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

NCBI and Uniprot Product Information

• NCBI GI #: 153792298
• NCBI GeneID: 440822
• NCBI Accession #: NP_001008496
• NCBI GenBank Nucleotide #: NM_001008496.3
• UniProt Accession #: P83110; Q7Z3Z3
• Molecular Weight: 101,089 Da
• NCBI Official Full Name: piwi-like protein 3 isoform 1
• NCBI Official Synonym Full Names: piwi-like RNA-mediated gene silencing 3
• NCBI Official Symbol: PIWIL3
• NCBI Official Synonym Symbols: HIWI3
• NCBI Protein Information: piwi-like protein 3; piwi-like 3
• UniProt Protein Name: Serine protease HTRA3
• Protein Family: Serine protease
• UniProt Gene Name: HTRA3
• UniProt Synonym Gene Names: PRSP
• UniProt Entry Name: HTRA3_HUMAN

NCBI Description

This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

HTRA3: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. Belongs to the peptidase S1B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.-; Secreted, signal peptide; Protease; Secreted

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: extracellular region

Molecular Function: insulin-like growth factor binding; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; endopeptidase activity

Biological Process: regulation of cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; proteolysis; negative regulation of BMP signaling pathway