Rabbit anti-Human HTRA3 Polyclonal Antibody | anti-HTRA3 antibody

HTRA3 Antibody

Cat. Num. AAA9401387

• Gene Names: HTRA3; Prsp; Tasp
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: HTRA3; Polyclonal Antibody; HTRA3 Antibody; Prsp; Tasp; anti-HTRA3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total HTRA3 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.7 mg/ml (varies by lot)
• Sequence Length: 357

• Applicable Applications for anti-HTRA3 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human HtrA serine peptidase 3
• Target Name: HTRA3
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/45.)

Related Product Information for anti-HTRA3 antibody

HtrA3, also known as PRSP (pregnancy-related serine protease), is a 453 amino acid secreted protein that contains one PDZ domain, one Kazal-like domain and one IGFBP N-terminal domain. Widely expressed with particularly high expression in ovary, heart, placenta and bladder, HtrA3 functions as a probable serine protease that is thought to play an important role in placental development. HtrA3 is downregulated in ovarian tumors, suggesting an alternative role in tumor suppression. HtrA3 exists as two alternatively spliced isoforms, designated short and long. The gene encoding HtrA3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Product Categories/Family for anti-HTRA3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 662236739
• NCBI GeneID: 94031
• NCBI Accession #: NP_001284488.1
• NCBI GenBank Nucleotide #: NM_001297559.1
• UniProt Accession #: P83110; Q7Z7A2
• Molecular Weight: 37,940 Da
• NCBI Official Full Name: serine protease HTRA3 isoform 2
• NCBI Official Synonym Full Names: HtrA serine peptidase 3
• NCBI Official Symbol: HTRA3
• NCBI Official Synonym Symbols: Prsp; Tasp
• NCBI Protein Information: serine protease HTRA3
• UniProt Protein Name: Serine protease HTRA3
• Protein Family: Serine protease
• UniProt Gene Name: HTRA3
• UniProt Synonym Gene Names: PRSP
• UniProt Entry Name: HTRA3_HUMAN

Uniprot Description

HTRA3: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. Belongs to the peptidase S1B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: extracellular region

Molecular Function: insulin-like growth factor binding; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; endopeptidase activity

Biological Process: regulation of cell growth; proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of BMP signaling pathway