Western Blot (WB)
(Western blot analysis of PIWI-L3 in 3T3 cell lysate with PIWI-L3 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Rabbit PIWI-L3 Polyclonal Antibody | anti-PIWI-L3 antibody
PIWI-L3 Antibody
Western Blot (WB)
(Western blot analysis of PIWI-L3 in 3T3 cell lysate with PIWI-L3 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of PIWI-L3 in 3T3 cell lysate with PIWI-L3 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
PIWIL3: May play a role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Belongs to the argonaute family. Piwi subfamily.
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: cytoplasm
Molecular Function: RNA binding
Biological Process: regulation of translation; meiotic cell cycle; multicellular organismal development; spermatogenesis; RNA-mediated gene silencing; cell differentiation
Research Articles on PIWI-L3
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Product Notes
The PIWI-L3 piwil3 (Catalog #AAA9410570) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PIWI-L3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PIWI-L3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the PIWI-L3 piwil3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PIWI-L3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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