Western Blot (WB)
(Western blot of rat cerebellum lysate showing specific immunolabeling of ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1244)
Rabbit GRIN2C Polyclonal Antibody | anti-GRIN2C antibody
GRIN2C antibody (Ser1244)
Western Blot (WB)
(Western blot of rat cerebellum lysate showing specific immunolabeling of ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1244)
Western Blot (WB)
(Western blot of rat cerebellum lysate showing specific immunolabeling of ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1244)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Description
NMDAR2C: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: postsynaptic membrane; integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein N-terminus binding; cation channel activity; PDZ domain binding
Biological Process: synaptic transmission; synaptic transmission, glutamatergic; protein localization; glutamate signaling pathway; directional locomotion; ionotropic glutamate receptor signaling pathway; transport; response to wounding; neuromuscular process controlling balance; regulation of excitatory postsynaptic membrane potential; negative regulation of protein catabolic process
Research Articles on GRIN2C
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Product Notes
The GRIN2C grin2c (Catalog #AAA837300) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's GRIN2C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000. Researchers should empirically determine the suitability of the GRIN2C grin2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRIN2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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