Immunohistochemistry (IHC)
(Anti-GPR68 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit GPR68 / OGR1 Polyclonal Antibody | anti-GPR68 antibody
Rabbit Polyclonal to Human GPR68 / OGR1
Gene Names
GPR68; OGR1; GPR12A
Reactivity
Gibbon, HumanPredicted Reactivity: Monkey, Mouse, Rat, Bovine, Hamster, Horse (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry, Immunocytochemistry, ELISA
Purity
Immunoaffinity Purified
Synonyms
GPR68 / OGR1; Polyclonal Antibody; Rabbit Polyclonal to Human GPR68 / OGR1; Anti-GPR68 / OGR1 Antibody (C-Terminus) IHC-plus; GPR68; Brgrb; G protein-coupled receptor 68; G-protein coupled receptor 68; OGR1; Brgr1; GPR12A; OGR-1; Human GPR68; anti-GPR68 antibody
Host
Rabbit
Reactivity
Gibbon, Human
Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Hamster, Horse (at least 90% immunogen sequence identity)
Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Hamster, Horse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human GPR68. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
365
Applicable Applications for anti-GPR68 antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes
ELISA, ICC, IHC-P (5 - 7.5 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from C-terminus of human GPR68. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%); Marmoset, Mouse, Rat, Bovine, Hamster, Elephant, Horse (95%); Rabbit (85%); Pig (80%).
Immunogen Type
Synthetic peptide
Immunogen
GPR68 / OGR1 antibody was raised against synthetic 20 amino acid peptide from C-terminus of human GPR68. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%); Marmoset, Mouse, Rat, Bovine, Hamster, Elephant, Horse (95%); Rabbit (85%); Pig (80%).
Antigen Modification
C-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Immunohistochemistry (IHC)
(Anti-GPR68 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-GPR68 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-GPR68 antibody
OGR1, a Lysophospholipid/Lysosphingolipid Receptor, was isolated by degenerate PCR from an ovarian cell line cDNA library. It is not expressed in normal ovary. OGR1 binds sphingosylphosporylcholine, a lipid molecule involved in cell growth and survival. Recently, OGR1 has been shown to act as a proton-sensing receptor stimulating inositol phosphate formation (Ludwig et al. 2003).
Product Categories/Family for anti-GPR68 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
41,077 Da
NCBI Official Full Name
ovarian cancer G-protein coupled receptor 1
NCBI Official Synonym Full Names
G protein-coupled receptor 68
NCBI Official Symbol
GPR68
NCBI Official Synonym Symbols
OGR1; GPR12A
NCBI Protein Information
ovarian cancer G-protein coupled receptor 1; G-protein coupled receptor 68; sphingosylphosphorylcholine receptor; ovarian cancer G protein-coupled receptor, 1
UniProt Protein Name
Ovarian cancer G-protein coupled receptor 1
Protein Family
UniProt Gene Name
GPR68
UniProt Synonym Gene Names
OGR1; OGR-1
UniProt Entry Name
OGR1_HUMAN
Uniprot Description
GPR68: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; Membrane protein, integral; Tumor suppressor; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 14q31
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; inflammatory response; negative regulation of monocyte differentiation
Research Articles on GPR68
Similar Products
Product Notes
The GPR68 gpr68 (Catalog #AAA243815) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human GPR68 / OGR1 reacts with Gibbon, Human Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Hamster, Horse (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's GPR68 / OGR1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), ELISA (EIA). ELISA, ICC, IHC-P (5 - 7.5 ug/ml). Researchers should empirically determine the suitability of the GPR68 gpr68 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPR68 / OGR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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