Rabbit anti-Human GPR3 Polyclonal Antibody | anti-GPR3 antibody

GPR3 antibody

Cat. Num. AAA535652

• Gene Names: GPR3; ACCA
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: GPR3 antibody was purified by affinity chromatography.
• Synonyms: GPR3; Polyclonal Antibody; GPR3 antibody; Polyclonal GPR3; Anti-GPR3; G protein-coupled receptor 3; gpcr3; gpr3; GPR -3; GPR 3; gpcr21; G protein-coupled receptor gpr3; anti-GPR3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human
• Purity/Purification: GPR3 antibody was purified by affinity chromatography.
• Form/Format: Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 330

• Applicable Applications for anti-GPR3 antibody: Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 40 ug/ml
• Biological Significance: GPR3 activates adenylate cyclase in the absence of ligand. GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue. It has been proposed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands, however this result was not confirmed in a Beta-arrestin recruitment assay.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
• Immunogen: GPR3 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-GPR3 antibody

Rabbit polyclonal GPR3 antibody

Product Categories/Family for anti-GPR3 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4885325
• NCBI GeneID: 2827
• NCBI Accession #: NP_005272.1
• NCBI GenBank Nucleotide #: NM_005281.2
• UniProt Accession #: P46089; A8K570
• Molecular Weight: 35,010 Da
• NCBI Official Full Name: G-protein coupled receptor 3
• NCBI Official Synonym Full Names: G protein-coupled receptor 3
• NCBI Official Symbol: GPR3
• NCBI Official Synonym Symbols: ACCA
• NCBI Protein Information: G-protein coupled receptor 3
• UniProt Protein Name: G-protein coupled receptor 3
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR3
• UniProt Synonym Gene Names: ACCA
• UniProt Entry Name: GPR3_HUMAN

NCBI Description

This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]

Uniprot Description

GPR3: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons and neurite outgrowth. Maintains also meiotic arrest in oocytes. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Cell cycle regulation; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.1-p35

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding

Biological Process: elevation of cytosolic calcium ion concentration; regulation of meiosis; positive regulation of cAMP metabolic process; G-protein signaling, adenylate cyclase activating pathway