Goat GABRA6 Polyclonal Antibody | anti-GABRA6 antibody

Goat Polyclonal to Human GABRA6

Cat. Num. AAA248220

• Reactivity: Gorilla, Human, Orangutan
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: GABRA6; Polyclonal Antibody; Goat Polyclonal to Human GABRA6; Anti-GABRA6 Antibody (aa15-26) IHC-plus; GABA A receptor alpha 6; GABA(A) receptor; alpha 6; Human GABRA6; anti-GABRA6 antibody

• Host: Goat
• Reactivity: Gorilla, Human, Orangutan
• Clonality: Polyclonal
• Specificity: Human GABRA6
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 453

• Applicable Applications for anti-GABRA6 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:128000), IHC-P (5 ug/ml); Usage: Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Preliminary experiments gave bands at approx 75kD and 37kD in Human Cerebellum lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanatio...
• Target Species: Human
• Immunogen Description: Synthetic peptide ENALGKLEVEGN-C from the N-terminus of human GABRA6 (NP_000802.2). Percent identity by BLAST analysis: Human, Gorilla, Orangutan (100%); Chimpanzee, Gibbon, Galago, Bovine, Horse (92%); Monkey, Marmoset, Panda, Dog, Rabbit (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: GABRA6 antibody was raised against synthetic peptide ENALGKLEVEGN-C from the N-terminus of human GABRA6 (NP_000802.2). Percent identity by BLAST analysis: Human, Gorilla, Orangutan (100%); Chimpanzee, Gibbon, Galago, Bovine, Horse (92%); Monkey, Marmoset, Panda, Dog, Rabbit (83%).
• Antigen Modification: aa15-26
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-GABRA6 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-GABRA6 antibody

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A receptor subtype. GABA-A receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A receptor is a multimeric subunit complex.

Product Categories/Family for anti-GABRA6 antibody

Family: Ion Channel; Subfamily: GABA A receptor

NCBI and Uniprot Product Information

• NCBI GI #: 157389018
• NCBI GeneID: 2559
• NCBI Accession #: NP_000802.2
• NCBI GenBank Nucleotide #: NM_000811.2
• UniProt Accession #: Q16445; Q4VAV2; A8K096
• Molecular Weight: 51,024 Da
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit alpha-6
• NCBI Official Synonym Full Names: gamma-aminobutyric acid (GABA) A receptor, alpha 6
• NCBI Official Symbol: GABRA6
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit alpha-6; GABA(A) receptor, alpha 6; GABA subunit A receptor alpha 6; GABA(A) receptor subunit alpha-6
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit alpha-6
• Protein Family: Gamma-aminobutyric acid receptor
• UniProt Gene Name: GABRA6
• UniProt Entry Name: GBRA6_HUMAN

NCBI Description

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

GABRA6: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily.

Protein type: Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass; Channel, chloride; Transporter

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; signal transduction; transmembrane transport; gamma-aminobutyric acid signaling pathway