Rabbit anti-Human, Mouse G Protein, alpha 16, Polyclonal Antibody | anti-GNA15 antibody

G Protein, alpha 16, (Ga16)

Cat. Num. AAA625035

• Gene Names: GNA15; GNA16
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: G Protein; alpha 16; ; Polyclonal Antibody; (Ga16); Anti -G Protein; anti-GNA15 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Reacts with Ga16. Recognizes human Ga16 and mouse Ga15, but not other G proteins.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in 0.05% sodium azide.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GNA15 antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in Western Blot and Immunoprecipitation.; Titer: Western Blot: 1:5000
• Immunogen: E. coli-expressed human Ga16 (aa237-373)
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-GNA15 antibody

Ga16 is the only heterotrimeric G proteins with a restricted expression pattern in hematopoietic cells. Differentiation of promyelocytic cells leads to decreased expression of Ga16. This G protein is known to couple a large number of G protein-coupled receptors to PLC-B and can lead to production of the secondary messengers diacylglycerol and inositol phosphates. Targeted deletion of Ga15, a mouse orthologue of human Ga16, causes reduced C5a receptor signaling. Ga16 serves as a marker, in addition to CD34, for hematopoietic progenitor cells.

Product Categories/Family for anti-GNA15 antibody

Antibodies; Abs to G Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 3289983
• NCBI GeneID: 2769
• UniProt Accession #: P30679; O75247; Q53XK2; E9KL40; E9KL47
• NCBI Official Full Name: GB15_HUMAN
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
• NCBI Official Symbol: GNA15
• NCBI Official Synonym Symbols: GNA16
• NCBI Protein Information: guanine nucleotide-binding protein subunit alpha-15; g alpha-15; g alpha-16; G-protein subunit alpha-15; G-protein subunit alpha-16; epididymis tissue protein Li 17E; guanine nucleotide-binding protein subunit alpha-16
• UniProt Protein Name: Guanine nucleotide-binding protein subunit alpha-15
• Protein Family: Guanine nucleotide-binding protein
• UniProt Gene Name: GNA15
• UniProt Synonym Gene Names: GNA16; G alpha-15; G-protein subunit alpha-15; G alpha-16
• UniProt Entry Name: GNA15_HUMAN

Uniprot Description

G-alpha 15: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Belongs to the G-alpha family. G(q) subfamily.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: plasma membrane; heterotrimeric G-protein complex

Molecular Function: GTPase activity; signal transducer activity; GTP binding; G-protein-coupled receptor binding; metal ion binding; G-protein beta/gamma-subunit binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; platelet activation; elevation of cytosolic calcium ion concentration; metabolic process; phospholipase C activation; dopamine receptor, phospholipase C activating pathway; blood coagulation; muscarinic acetylcholine receptor, phospholipase C activating pathway